ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2017
EVALUATION OF THE ANTI-INFLAMMATORY CAPACITY OF BETA-SITOSTEROL IN RODENT ASSAYS.
Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
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- Bioassay-guided fractionation and identification of wound healing active compounds from Khaya senegalensis leaves.PloS one · 2026Article
- Biochemical investigations, in silico study and targeted delivery aspects of plant phytosterols: β-sitosterol.Inflammopharmacology · 2025Review
- Exploreing the potential mechanism of Aitongxiao formula inhibiting hepatocellular carcinoma in vitro and in vivo based on network Pharmacology.Scientific reports · 2025Article
- Efficacy of Phlai (Life (Basel, Switzerland) · 2025Article
- Exploring the Anti-Osteoporotic Effects ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Aspects of β-sitosterol's Pharmacology, Nutrition and Analysis.Current pharmaceutical biotechnology · 2025Review
- Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract.PloS one · 2025Article
- β-sitosterol alleviated HFD-induced atherosclerosis by regulating the MAPK/Nrf2/NLRP3 pathway in ApoE-/- mice.PloS one · 2025Article
- Endophytic fungi from Cissus quadrangularis plant a promising source of bioactive compounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug.Inflammopharmacology · 2024Article
- Exploring the therapeutic effect of core components in Xuanshen Yishen mixture on hypertension through network pharmacology.American journal of translational research · 2024Article
- Sterols in Inflammatory Diseases: Implications and Clinical Utility.Advances in experimental medicine and biology · 2024Review
- Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren's syndrome (SS) using network pharmacology and animal experiment.Pharmaceutical biology · 2023Article
- Article
- Anti-Inflammatory Potential of Pteropodine in Rodents.Metabolites · 2023Article
- Phytochemical Analysis and Anti-Inflammatory Potential ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Bioactive steroids from seed germination supporting fungus (Mycology · 2023Article
- Exploring Myocardial Ischemia-Reperfusion Injury Mechanism of Cinnamon by Network Pharmacology, Molecular Docking, and Experiment Validation.Computational and mathematical methods in medicine · 2023Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBeta-sitosterol (BS) is a compound discovered to be present in numerous plants. A number of interesting biomedical properties have been attributed to BS, including immuno-modulating and anti-inflammatory activities. Therefore, the aim of this report was to evaluate its anti-inflammatory capacity by applying various rodent experimental tests.
methodsTo carry out the objective of the study we applied the methods indicated here. Two of the adopted methods were based on the passive reverse Arthus reaction: the rat paw edema test and the rat pleurisy assay. We also applied two methods related with the non-specific acute inflammation: the mouse ear edema test, and the mouse mieloperoxidase activity assay.
resultsThe results obtained in all tests established a significant anti-inflammatory potential of BS. In the rat paw edema test we found an inhibitory effect which goes from 50-70%; in the rat pleurisy assay our findings with respect to the volume of pleural exuded showed a reduction of 46%, as well as a 20% low amount of neutrophils in comparison with the level of the control group. In the mouse ear edema test we found a mean inflammatory inhibition of 75%, and with respect to mieloproxidase activity the results showed a significant inhibition induced by the three doses of BS.
conclusionsIn the present study we determined a potent anti-inflammatory capacity of BS in specific and non-specific types of acute inflammation in rodents.
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