Trial reportScientific reports2017
Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.
Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 85 citations in OpenAlex.
- Long-acting intranasal insulin for the treatment of delirium-a randomised clinical trial.Age and ageing · 2025Trial
- Daily intranasal insulin at 40IU does not affect food intake and body composition: A placebo-controlled trial in older adults over a 24-week period with 24-weeks of follow-up.Clinical nutrition (Edinburgh, Scotland) · 2023Trial
- Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese.JCI insight · 2022Trial
- The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study.International journal of obesity (2005) · 2022Trial
- Trial
- Is abnormal brain insulin action implicated in the biology of depression? A pilot neuroimaging study in adolescents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Unhealthy fat distribution as a sex-specific predictor of declining hippocampus insulin sensitivity.Diabetologia · 2026Article
- Redefining the timeline: a three-phase framework of hypothalamic microinflammation in metabolic disease.Reviews in endocrine & metabolic disorders · 2026Review
- Metabolic Contributions to Learning and Feeling: Why They Matter and How to Make the Most of Them.Biological psychiatry global open science · 2026Article
- Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications.Nutrients · 2026Review
- Metabolism and the Mind: Investigating the Link Between Glucose Control and Reinforcement Learning in Humans.Biological psychiatry global open science · 2026Article
- The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women.Communications biology · 2026Article
- Expanding the understanding of insulin resistance in brain and periphery.Trends in endocrinology and metabolism: TEM · 2026Review
- Association between metabolic syndrome, diabetes mellitus, inflammation and cognitive dysfunctions in schizophrenia: a cross-sectional analysis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Transcranial Direct Current Stimulation (tDCS) in Diabetes: A Focused and Mechanistic Review of Symptom and Function Outcomes.Journal of clinical medicine · 2025Review
- The brain-white adipose tissue axis may play a crucial role in diabetes mellitus: a metabolic network analysis using total-body PET/CT imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- A systematic review of in vivo brain insulin resistance biomarkers in humans.Biomarkers in neuropsychiatry · 2025Review
- A short-term, high-caloric diet has prolonged effects on brain insulin action in men.Nature metabolism · 2025Article
- Insulin Resistance-related Gray Matter Volume Reduction is Associated with the Default Mode Network.Juntendo medical journal · 2025Article
- State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease.Aging and disease · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-five lean and twenty-two overweight and obese participants underwent functional magnetic resonance imaging, on two separate days, before and after intranasal insulin or placebo application. Insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. The change in hippocampal functional connectivity significantly correlated with visceral adipose tissue and the change in subjective feeling of hunger after intranasal insulin. Mediation analysis revealed that the intranasal insulin induced hippocampal functional connectivity increase served as a mediator, suppressing the relationship between visceral adipose tissue and hunger. The insulin-induced hypothalamic functional connectivity change showed a significant interaction with peripheral insulin sensitivity. Only participants with high peripheral insulin sensitivity showed a boost in hypothalamic functional connectivity. Hence, brain insulin action may regulate eating behavior and facilitate weight loss by modifying brain functional connectivity within and between cognitive and homeostatic brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.