ReviewFrontiers in molecular neuroscience2017
Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss.
Review in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Omega-3 fatty acids and health of auditory and vestibular systems: a comprehensive review.European journal of nutrition · 2024Review
- Hearing and Diet (Narrative Review).Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Omega-3 Adjunctive Therapy in Idiopathic SSNHL: A Randomised, Triple-Blind, Placebo-Controlled Trial.Iranian journal of otorhinolaryngology · 2023Article
- Dietary intake, nutritional adequacy and food sources of vitamins involved in the methionine-methylation cycle from Spanish children aged one to <10 years: results from the EsNuPI study.Frontiers in nutrition · 2023Article
- Immediate-Early Modifications to the Metabolomic Profile of the Perilymph Following an Acoustic Trauma in a Sheep Model.Journal of clinical medicine · 2022Article
- SLC26A4 Mutation Promotes Cell Apoptosis by Inducing Pendrin Transfer, Reducing ClBioMed research international · 2022Article
- Article
- Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model.Neural plasticity · 2021Article
- Article
- Audiological and otologic manifestations of glutaric aciduria type I.Orphanet journal of rare diseases · 2020Article
- Diet quality and hearing loss among middle-older aged adults in the USA: findings from National Health and Nutrition Examination Survey.Public health nutrition · 2020Article
- miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the MouseFrontiers in cell and developmental biology · 2020Article
- Determining the effect of folate diets during pregnancy and lactation on neurobehavioural changes in the adult life of offspring.Journal of Taibah University Medical Sciences · 2019Article
- Betaine-homocysteineFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Association of Nutritional Factors with Hearing Loss.Nutrients · 2019Review
- Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes.Nutrients · 2019Article
- Interplay between Nutrition and Hearing Loss: State of Art.Nutrients · 2018Review
- Erythrocyte folate, serum vitamin B12, and hearing loss in the 2003-2004 National Health And Nutrition Examination Survey (NHANES).European journal of clinical nutrition · 2018Article
- The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss.Frontiers in aging neuroscience · 2017Review
- Association of Hearing Loss and Eating Habits in the Older Population.American journal of lifestyle medicineReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic substances and aging playing a role. The nutritional status is central in aging disability, but the interplay between nutrition and SNHL has only recently gained attention. Dietary supplementation could therefore constitute the first step for the prevention and potential repair of hearing damage before it reaches irreversibility. In this context, different epidemiological studies have shown correlations among the nutritional condition, increased total plasma homocysteine (tHcy) and SNHL. Several human genetic rare diseases are also associated with homocysteine (Hcy) metabolism and SNHL confirming this potential link. Accordingly, rodent experimental models have provided the molecular basis to understand the observed effects. Thus, increased tHcy levels and vitamin deficiencies, such as folic acid (FA), have been linked with SNHL, whereas long-term dietary supplementation with omega-3 fatty acids improved Hcy metabolism, cell survival and hearing acuity. Furthermore, pharmacological supplementations with the anti-oxidant fumaric acid that targets Hcy metabolism also improved SNHL. Overall these results strongly suggest that cochlear Hcy metabolism is a key player in the onset and progression of SNHL, opening the way for the design of prospective nutritional therapies.
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