Evidence map›Paper›PMID 28495969›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Fold-change detection and scale invariance of cell-cell signaling in social amoeba.

Keita Kamino, Yohei Kondo, Akihiko Nakajima, Mai Honda-Kitahara, Kunihiko Kaneko, Satoshi Sawai

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 52 citations in OpenAlex.

  1. Many Cells Make Light Work: Self-Generated Gradients OrganizeCold Spring Harbor perspectives in biology · 2026
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  9. Optimal inference of molecular interaction dynamics in FRET microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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  13. A yeast FRET biosensor enlightens cAMP signaling.Molecular biology of the cell · 2021
    Article
  14. Fold Change Detection in Visual Processing.Frontiers in neural circuits · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Keita KaminoDepartment of Basic Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan; cssawai@mail.ecc.u-tokyo.ac.jp k.kamino@amolf.nl.
Yohei KondoDepartment of Basic Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.ORCID 0000-0002-2801-4522
Akihiko NakajimaResearch Center for Complex Systems Biology, University of Tokyo, Tokyo 153-8902, Japan.
Mai Honda-KitaharaDepartment of Basic Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.
Kunihiko KanekoDepartment of Basic Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.
Satoshi SawaiDepartment of Basic Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan; cssawai@mail.ecc.u-tokyo.ac.jp k.kamino@amolf.nl.ORCID 0000-0003-3764-219X
Tokyo University of the Arts · JPSystems Biology Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-cell signaling is subject to variability in the extracellular volume, cell number, and dilution that potentially increase uncertainty in the absolute concentrations of the extracellular signaling molecules. To direct cell aggregation, the social amoebae

Indexed as

Paracrine CommunicationCyclic AMPDictyosteliumCyclic AMPcollective behaviorDictyosteliumfold-change detectionoscillationsrobustness

Identifiers

PMID28495969
PMCPMC5448168
OpenAlexW2612772204

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.