ArticlePsychosomatic medicine2017
Fornix Structural Connectivity and Allostatic Load: Empirical Evidence From Schizophrenia Patients and Healthy Controls.
Article in Psychosomatic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis.Translational psychiatry · 2025Pooled it
- Allostatic load index across the psychosis spectrum: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research.International journal of environmental research and public health · 2022Pooled it
- Role of White Matter Microstructure in Impulsive Behavior.The Journal of neuropsychiatry and clinical neurosciences · 2022Pooled it
- Peripheral Microvascular and Cerebral White Matter Dysfunction in Schizophrenia: Implications of a Body-Brain Endothelial Pathophysiology.Schizophrenia bulletin · 2025Article
- Disparities in Allostatic Load Among Different Races: A Comprehensive Scoping Review.Journal of racial and ethnic health disparities · 2025Review
- Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.NeuroImage · 2025Article
- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration.Current topics in behavioral neurosciences · 2025Review
- Elucidating individual differences in chronic pain and whole person health with allostatic load biomarkers.Brain, behavior, & immunity - health · 2023Article
- A Preliminary Report: The Hippocampus and Surrounding Temporal Cortex of Patients With Schizophrenia Have Impaired Blood-Brain Barrier.Frontiers in human neuroscience · 2022Article
- White matter in prolonged glucocorticoid response to psychological stress in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia.Schizophrenia bulletin · 2021Article
- Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review.Brain connectivity · 2020Review
- Choroid Plexus Enlargement and Allostatic Load in Schizophrenia.Schizophrenia bulletin · 2020Article
- Stress, Allostatic Load, and Psychosis: One Step Forward in Research But Where to Go Next?Frontiers in psychiatry · 2019Article
- Elevated allostatic load early in the course of schizophrenia.Translational psychiatry · 2018Article
- Allostatic load and disordered white matter microstructure in overweight adults.Scientific reports · 2018Article
- Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study.Scientific reports · 2018Article
- Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status.Frontiers in human neuroscience · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe fornix is a white matter tract carrying the fibers connecting the hippocampus and the hypothalamus, two essential stress-regulatory structures of the brain. We tested the hypothesis that allostatic load (AL), derived from a battery of peripheral biomarkers indexing the cumulative effects of stress, is associated with abnormalities in brain white matter microstructure, especially the fornix, and that higher AL may help explain the white matter abnormalities in schizophrenia.
methodsUsing 13 predefined biomarkers, we tested AL in 44 schizophrenic patients and 33 healthy controls. Diffusion tensor imaging was used to obtain fractional anisotropy (FA) values of the fornix and other white matter tracts.
resultsAL scores were significantly elevated in patients compared with controls (F(3,77) = 7.87, p = .006). AL was significantly and inversely correlated with FA of fornix in both controls (r = -.58, p = .001) and patients (r = -.36, p = .023). Several nominally significant (p < .05 but did not survive Bonferroni correction for multiple comparison) correlations were also observed between AL and FA of other white matter tracts in schizophrenic patients. However, the fornix was the only tract exhibiting a correlation with AL in both groups.
conclusionsThese results provide initial evidence that allostatic processes are linked to fornix microstructure in clinical participants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.