Evidence map›Paper›PMID 28503402›Full record

ArticleCurrent behavioral neuroscience reports2016

Physical Exercise for Treatment of Mood Disorders: A Critical Review.

C M Hearing, W C Chang, K L Szuhany, T Deckersbach, A A Nierenberg, L G Sylvia

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current behavioral neuroscience reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03895450 nacompletednot on this mapstarted 2019, after this paper: background citation

Improving Symptom Burden in Individuals With Persistent Post Concussive Symptoms: A Step-wise Aerobic Exercise Trial

TypeinterventionalSponsorUniversity of CalgaryRan2019 to 2023Enrolled52ConditionsBrain Injuries, Traumatic, Concussion, Brain, Mild Traumatic Brain Injury, Post-Concussion SyndromeArmsAerobic Exercise Protocol, Stretching Protocol
NCT04346836 nacompletednot on this mapstarted 2018, after this paper: background citation

Low-intensity Exercise as a Predictor of Mental Health in Women With Metabolic Syndrome

TypeinterventionalSponsorWroclaw University of Health and Sport SciencesRan2018 to 2020Enrolled88ConditionsMetabolic Syndrome, Obesity, Hypertension, HyperlipidemiasArmsLow-intensity, general-fitness exercises, Psychoeducation
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  6. The UP150: A Multifactorial Environmental Intervention to Promote Employee Physical and Mental Well-Being.International journal of environmental research and public health · 2022
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  14. Patterns of shared genetic risk between chronic pain, psychopathologies, and neuroticism.Clinical psychological science : a journal of the Association for Psychological Science · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C M HearingDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. Phone number: 866-996-6637.
W C ChangDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. Phone number: 866-996-6637.
K L SzuhanyDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA. Phone number: 617-353-9610.
T DeckersbachDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Phone number: 866-996-6637.
A A NierenbergDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Phone number: 866-996-6637.
L G SylviaDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Phone number: 866-996-6637.

Funding

NIMH NIH HHS K23 MH091182
6 · The paper itself

Abstract

purpose of the reviewThe purpose of this review is to critically assess the evidence for exercise as an adjunct intervention for major depressive disorder and bipolar disorder, chronic conditions characterized by frequent comorbid conditions as well as interepisodic symptoms with poor quality of life and impaired functioning. Individuals with these mood disorders are at higher risk of cardiovascular disease and premature death in part because of increased rates of obesity, inactivity, and diabetes mellitus compared to the general population. Exercise may not only mitigate the increased risk of cardiovascular disease, but could also potentially improve the long term outcomes of mood disorders. RECENT

findingsWe conducted a literature review on the impact of exercise on mood disorders and associated comorbid conditions as well as possible biological mechanisms. We found that exercise impacts both the physical health parameters of mood disorders as well as mental health outcomes. Exercise also positively impacts conditions frequently comorbid with mood disorders (i.e. anxiety, pain, and insomnia). There are multiple candidate biomarkers for exercise, with brain-derived neurotrophic factor and oxidative stress as two main promising components of exercise's anti-depressant effect. SUMMARY: Exercise appears to be a promising adjunct treatment for mood disorders. We conclude with recommendations for future research of exercise as an adjunct intervention for mood disorders.

Indexed as

adjunctive interventionBipolar disordercardiovascular diseasedepressionexercisemood disorders

Identifiers

PMID28503402
PMCPMC5423723

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.