Evidence map›Paper›PMID 28510619›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study.

Priya Palta, Michelle C Carlson, Rosa M Crum, Elizabeth Colantuoni, A Richey Sharrett, Sevil Yasar, Richard L Nahin, Steven T DeKosky, Beth Snitz, Oscar Lopez and 4 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Diabetes-Specific Dementia: A Structured Literature Review of Cognitive Assessment Methods.The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
    Pooled it
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  19. The Role of Iron Overload in Diabetic Cognitive Impairment: A Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Priya PaltaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Michelle C CarlsonDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Rosa M CrumDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Elizabeth ColantuoniDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
A Richey SharrettDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Sevil YasarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Richard L NahinNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland.
Steven T DeKoskyDepartment of Neurology, University of Florida College of Medicine, Gainesville.
Beth SnitzDepartment of Neurology, University of Pittsburgh, Pennsylvania.
Oscar LopezDepartment of Neurology, University of Pittsburgh, Pennsylvania.
Jeff D WilliamsonDivision of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Curt D FurbergDivision of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Stephen R RappDivision of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Sherita Hill GoldenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USWake Forest University · USUniversity of Pittsburgh · USFlorida College · USNational Center for Complementary and Integrative Health · US

Funding

Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Clinical Research&Epidemiology in Diabetes&EndocrinologyT32DK062707 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Wendy Lynet Bennett · 2002 to 2026
$7.3M
Cardiometabolic Health in Adolescents of South Asian Ancestry - the CHAriSmA studyR01DK115648 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MAGGE, SHEELA NATESH · 2018 to 2022
$3.9M
Physical Activity and Preservation of Cognitive FunctionK99AG052830 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PALTA, PRIYA · 2016 to 2017
$151k
NHLBI NIH HHS T32 HL007055NIA NIH HHS K99 AG052830NIDDK NIH HHS R01 DK115648NIDDK NIH HHS T32 DK062707NIMHD NIH HHS L60 MD009349
6 · The paper itself

Abstract

backgroundPrevious studies have shown that individuals with diabetes exhibit accelerated cognitive decline. However, methodological limitations have limited the quality of this evidence. Heterogeneity in study design, cognitive test administration, and methods of analysis of cognitive data have made it difficult to synthesize and translate findings to practice. We analyzed longitudinal data from the Ginkgo Evaluation of Memory Study to test our hypothesis that older adults with diabetes have greater test-specific and domain-specific cognitive declines compared to older adults without diabetes.

methodsTests of memory, visuo-spatial construction, language, psychomotor speed, and executive function were administered. Test scores were standardized to z-scores and averaged to yield domain scores. Linear random effects models were used to compare baseline differences and changes over time in test and domain scores among individuals with and without diabetes.

resultsAmong the 3,069 adults, aged 72-96 years, 9.3% reported diabetes. Over a median follow-up of 6.1 years, participants with diabetes exhibited greater baseline differences in a test of executive function (trail making test, Part B) and greater declines in a test of language (phonemic verbal fluency). For the composite cognitive domain scores, participants with diabetes exhibited lower baseline executive function and global cognition domain scores, but no significant differences in the rate of decline.

conclusionsIdentifying cognitive domains most affected by diabetes can lead to targeted risk modification, possibly in the form of lifestyle interventions such as diet and physical activity, which we know to be beneficial for improving vascular risk factors, such as diabetes, and therefore may reduce the risk of executive dysfunction and possible dementia.

Indexed as

Ginkgo bilobaAgedAged, 80 and overCognitionCognitive DysfunctionDiabetes MellitusDouble-Blind MethodExecutive FunctionFemaleFollow-Up StudiesHumansMaleMemoryNeuropsychological TestsPlant ExtractsTime FactorsPlant ExtractsDiabetesDomain-specific cognitionEpidemiologyExecutive functionPsychomotor speed

Identifiers

PMID28510619
PMCPMC5861864
OpenAlexW2614624164

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.