Evidence map›Paper›PMID 28511845›Full record

ArticleDevelopmental biology2017

miR-205 is a critical regulator of lacrimal gland development.

D'Juan T Farmer, Jennifer K Finley, Feeling Y Chen, Estefania Tarifeño-Saldivia, Nancy A McNamara, Sarah M Knox, Michael T McManus

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. miR‑205: A dual regulator of angiogenesis in health and disease (Review).International journal of molecular medicine · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

D'Juan T FarmerDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA; UCSF Diabetes Center, University of California, San Francisco, CA, USA; WM Keck Center for Noncoding RNAs, University of California, San Francisco, CA, USA.
Jennifer K FinleyProgram in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA, USA.
Feeling Y ChenFrancis I. Proctor Foundation, University of California, San Francisco, CA, USA.
Estefania Tarifeño-SaldiviaDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA; UCSF Diabetes Center, University of California, San Francisco, CA, USA; WM Keck Center for Noncoding RNAs, University of California, San Francisco, CA, USA.
Nancy A McNamaraFrancis I. Proctor Foundation, University of California, San Francisco, CA, USA.
Sarah M KnoxProgram in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA, USA.
Michael T McManusDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA; UCSF Diabetes Center, University of California, San Francisco, CA, USA; WM Keck Center for Noncoding RNAs, University of California, San Francisco, CA, USA. Electronic address: michael.mcmanus@ucsf.edu.
University of California, San Francisco · US

Funding

SidTI/2-dependent EC-RNA Biogenesis and UptalceU19CA179513 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2013 to 2017
$8.3M
NCI NIH HHS U19 CA179513
6 · The paper itself

Abstract

The tear film protects the terrestrial animal's ocular surface and the lacrimal gland provides important aqueous secretions necessary for its maintenance. Despite the importance of the lacrimal gland in ocular health, molecular aspects of its development remain poorly understood. We have identified a noncoding RNA (miR-205) as an important gene for lacrimal gland development. Mice lacking miR-205 fail to properly develop lacrimal glands, establishing this noncoding RNA as a key regulator of lacrimal gland development. Specifically, more than half of knockout lacrimal glands never initiated, suggesting a critical role of miR-205 at the earliest stages of lacrimal gland development. RNA-seq analysis uncovered several up-regulated miR-205 targets that may interfere with signaling to impair lacrimal gland initiation. Supporting this data, combinatorial epistatic deletion of Fgf10, the driver of lacrimal gland initiation, and miR-205 in mice exacerbates the lacrimal gland phenotype. We develop a molecular rheostat model where miR-205 modulates signaling pathways related to Fgf10 in order to regulate glandular development. These data show that a single microRNA is a key regulator for early lacrimal gland development in mice and highlights the important role of microRNAs during organogenesis.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsFibroblast Growth Factor 10Fluorescent Antibody TechniqueGene Expression ProfilingLacrimal ApparatusMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroRNAsOrganogenesisReverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNASignal TransductionFgf10 protein, mouseFibroblast Growth Factor 10MicroRNAsMIRN205 microRNA, mouseFgf10Lacrimal glandMicroRNAsMiR-205

Identifiers

PMID28511845
PMCPMC9276161
OpenAlexW2612956112

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.