SynthesisJournal of lipid research2017
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 2 pooled it
10.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS meta-analysis, biological network construction, and structural modeling.Scientific reports · 2025Pooled it
- Genome-Wide Association Study HighlightsArteriosclerosis, thrombosis, and vascular biology · 2021Pooled it
- A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population.Journal of lipid research · 2019Trial
- Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin.Journal of the American Heart Association · 2018Trial
- Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study.Circulation. Genomic and precision medicine · 2018Trial
- Mendelian Randomization Reveals Interleukin-6 Receptor-Lipoprotein(a) Interplay With Independent Cardiovascular Risk Reductions.JACC. Basic to translational science · 2026Article
- Lipoprotein(a) in Coronary Artery Disease and Aortic Stenosis: Pathophysiology, Clinical Impact, Interventional Implications and Emerging Targeted Therapies.Journal of clinical medicine · 2026Review
- Article
- Baseline self-reported supplement category use and two-visit difference in lipoprotein(a): an observational analysis in UK Biobank.Lipids in health and disease · 2026Observational
- An introduction to polygenic scores - methodological basics and recent advances.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
- Lipoprotein(a) in Cardiovascular Diseases and Emerging Therapeutic Strategies.Cardiovascular drugs and therapy · 2026Review
- The Emerging Lipid Risk: Lipoprotein(a).Korean circulation journal · 2026Review
- Recent advances in understanding the spectrum of genetic determinants of lipoprotein(a) levels.Current opinion in lipidology · 2026Review
- A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans.Nature communications · 2026Article
- Lp(a), platelet count, aspirin and cardiovascular outcome: a prospective cohort analysis.Frontiers in cardiovascular medicine · 2026Article
- Genetic architecture of human aging and longevity: Insights from genome-wide association studies.BMB reports · 2026Review
- Polygenic modeling of genetic effects on both phenotypic mean and variance: distributional regression for BMI, blood and urine biomarkers in the UK Biobank.Frontiers in bioinformatics · 2026Article
- Lipoprotein(a) in clinical practice: Risk stratification and therapeutic strategies.European journal of clinical investigation · 2026Review
- Targeting Lipoprotein(a): A New Era in Cardiovascular Disease Prevention.Methodist DeBakey cardiovascular journal · 2026Review
- Diabetes Mellitus and Lipoprotein(a): A Determinant Interaction in Micro- and Macrovascular Damage.International journal of molecular sciences · 2025Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors at 13 institutions in 7 countries.
Salome MackDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Stefan CoassinDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Rico RueediDepartment of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Noha A YousriDepartment of Physiology and Biophysics, Weill Cornell Medical College-Qatar, Doha, Qatar; Department of Computer and Systems Engineering, Alexandria University, 21526 Alexandria, Egypt.
Ilkka SeppäläDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, 33520 Tampere, Finland.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Sebastian SchönherrDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Lukas ForerDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Gertraud ErhartDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, 1015 Lausanne, Switzerland.
Janina S RiedInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Gerard WaeberDepartment of Medicine, Internal Medicine, Lausanne University Hospital, 1015 Lausanne, Switzerland.
Sven BergmannDepartment of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Doreen DähnhardtDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Andrea StöcklDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Olli T RaitakariDepartment of Clinical Physiology, Turku University Hospital, 20520 Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and University of Tampere, 33521 Tampere, Finland.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany; German Centre for Cardiovascular Research (DZHK), 80802 Munich, Germany; German Center for Diabetes Research (DZD e.V.), 85764 Neuherberg, Germany.
Thomas MeitingerInstitute of Human Genetics, Technische Universität München, 81675 München, Germany; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
Ludmilla KedenkoFirst Department of Internal Medicine, Paracelsus Private Medical University, 5020 Salzburg, Austria.
Bernhard PaulweberFirst Department of Internal Medicine, Paracelsus Private Medical University, 5020 Salzburg, Austria.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, 33520 Tampere, Finland.
Steven C HuntCardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT 84108; Department of Genetic Medicine, Weill Cornell Medicine, Doha, Qatar.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, 1015 Lausanne, Switzerland.
Claudia LaminaDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria. Electronic address: Claudia.Lamina@i-med.ac.at.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria. Electronic address: Florian.Kronenberg@i-med.ac.at.
Innsbruck Medical University · ATUniversity of Lausanne · CHHelmholtz Zentrum München · DEParacelsus Medical University · ATTampere University · FIUniversität Innsbruck · ATDeutsches Diabetes-Zentrum e.V. · DEFimlab (Finland) · FISIB Swiss Institute of Bioinformatics · CHUniversity of Turku · FIUniversity of Utah · USWeill Cornell Medical College in Qatar · QAZimmer Biomet (Germany) · DE
Funding
GENCAC-Data Coordinating CenterU01HL067899 · NHLBI · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A · 2001 to 2004
$1.4MGENCAC - Utah Field CenterU01HL067894 · NHLBI · UNIVERSITY OF UTAH · PI HUNT, STEVEN C. · 2001 to 2004
$1.3MGENCAC - Arterial Calcium Reading CenterU01HL067897 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CARR, JOHN JEFFREY · 2001 to 2004
$1.2MGENCAC - Minnesota Field CenterU01HL067901 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PANKOW, JAMES S · 2001 to 2004
$1.1MGENCAC - Birmingham Field CenterU01HL067898 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2004
$1.0MGENCAC - MOLECULAR GENETICS LABORATORYU01HL067902 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HIXSON, JAMES E. · 2001 to 2004
$1.0MGENCAC - North Carolina Field CenterU01HL067895 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2001 to 2004
$989kGENCAC - Framingham Field CenterU01HL067896 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ELLISON, CURTIS R. · 2001 to 2004
$971kGENCAC - CENTRAL BIOCHEMISTRY LABORATORYU01HL067900 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ECKFELDT, JOHN H · 2001 to 2004
$884kGenetics of Coronary and Aortic Calcification (GENCAC)U01HL067893 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI HEISS, GERARDO · 2001 to 2004
$818kAustrian Science Fund FWF P 26660NHLBI NIH HHS U01 HL067893NHLBI NIH HHS U01 HL067894NHLBI NIH HHS U01 HL067895NHLBI NIH HHS U01 HL067896NHLBI NIH HHS U01 HL067897NHLBI NIH HHS U01 HL067898NHLBI NIH HHS U01 HL067899NHLBI NIH HHS U01 HL067900NHLBI NIH HHS U01 HL067901NHLBI NIH HHS U01 HL067902
Abstract
High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms. We aimed to identify genetic loci associated with Lp(a) concentrations using data from five genome-wide association studies (n = 13,781). We identified 48 independent SNPs in the
Indexed as
AnimalsApolipoproteins AGenome-Wide Association StudyHumansLipoprotein(a)Polymorphism, Single NucleotideProtein IsoformsSex CharacteristicsApolipoproteins ALipoprotein(a)Protein Isoformscoronary artery diseaseepidemiologygenetics
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.