ArticleBMC complementary and alternative medicine2017
Membrane of Candida albicans as a target of berberine.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Berberine as a Promising Antifungal Agent: Insights into Molecular Mechanisms and Therapeutic Potential.ACS omega · 2026Review
- Berberine Toxicity Profile in Experimental Models as a Basis for Assessing Its Biological Safety.Molecules (Basel, Switzerland) · 2026Article
- In Vitro Activity of Rezafungin Against Planktonic and Biofilm Forms ofPharmaceutics · 2026Article
- Berberine-ZnO loaded chitosan nanoparticles inhibits biofilm formation in Pseudomonas aeruginosa PAO1 through targeting extracellular polymeric substances.BMC biotechnology · 2026Article
- Article
- Antimicrobial activity, ergosterol content and phytochemical screening of Rorippa Islandica (Oeder ex Murr.) and Carrichtera annua (L.).Scientific reports · 2025Article
- Inhibitory effects of berberine againstMicrobiology spectrum · 2025Article
- Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance.Journal of fungi (Basel, Switzerland) · 2025Article
- Fungistatic activity and mechanism ofNarra J · 2025Article
- Inhibitory effects of berberine on fungal growth, biofilm formation, virulence, and drug resistance as an antifungal drug and adjuvant with prospects for future applications.World journal of microbiology & biotechnology · 2024Review
- The Antifungal Effects of Berberine and Its Proposed Mechanism of Action Through CYP51 Inhibition, as Predicted by Molecular Docking and Binding Analysis.Molecules (Basel, Switzerland) · 2024Article
- Spectrum of activity and mechanisms of azole-bisphosphonate synergy in pathogenicMicrobiology spectrum · 2024Article
- Berberine disrupts staphylococcal proton motive force to cause potent anti-staphylococcal effectsBiofilm · 2023Article
- Plasma activated Ezhangfeng Cuji as innovative antifungal agent and its inactivation mechanism.AMB Express · 2023Article
- Phytochemicals as Antimicrobials: Prospecting Himalayan Medicinal Plants as Source of Alternate Medicine to Combat Antimicrobial Resistance.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Phenothiazines Rapidly Induce Laccase Expression and Lignin-Degrading Properties in the White-Rot FungusJournal of fungi (Basel, Switzerland) · 2023Article
- The effect of herbal medicine in innate immunity toFrontiers in immunology · 2023Review
- The antibacterial activity of berberine againstFrontiers in microbiology · 2023Article
- Novel Preclinical Study of Galloylquinic Acid Compounds fromMicrobiology spectrum · 2022Article
- Lycosin-II Exhibits Antifungal Activity and Inhibits Dual-Species Biofilm byJournal of fungi (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species.
methodsThe effects on membrane, morphological transition, synthesis of ergosterol and the consequent changes in membrane permeability have been studied. Polarization and lipid peroxidation level of the membrane following berberine treatment have been addressed.
resultsMinimal inhibitory concentration (MIC) of berberine against C. albicans was 17.75 μg/mL. Cytotoxic effect of berberine was concentration dependent, and in sub-MIC concentrations inhibit morphological transition of C. albicans cells to its filamentous form. Results showed that berberine affects synthesis of membrane ergosterol dose-dependently and induces increased membrane permeability causing loss of intracellular material to the outer space (DNA/protein leakage). Berberine also caused membrane depolarization and lipid peroxidation of membrane constituents indicating its direct effect on the membrane. Moreover, ROS levels were also increased following berberine treatment indicating further the possibility of membrane damage.
conclusionBased on the obtained results it seems that berberine achieves its anti-Candida activity by affecting the cell membrane.
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