ArticleSchizophrenia bulletin2018
Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group.Molecular psychiatry · 2021Pooled it
- A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder.Brain imaging and behavior · 2019Pooled it
- Molecular Regulation of Fetal Brain Development in Inbred and Congenic Mouse Strains Differing in Longevity.Genes · 2024Article
- Differential DNA Methylation Is Associated With Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Network modules linking expression and methylation in prefrontal cortex of schizophrenia.Epigenetics · 2021Article
- DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury.Clinical epigenetics · 2021Article
- Sparse deep neural networks on imaging genetics for schizophrenia case-control classification.Human brain mapping · 2021Article
- Clinical Correlates of the NR3C1 Gene Methylation at Various Stages of Psychosis.The international journal of neuropsychopharmacology · 2021Article
- Editorial: Identifying Neuroimaging-Based Markers for Distinguishing Brain Disorders.Frontiers in neuroscience · 2020Article
- Multi-omics integrative analysis identified SNP-methylation-mRNA: Interaction in peripheral blood mononuclear cells.Journal of cellular and molecular medicine · 2019Article
- The Translational Potential of Neuroimaging Genomic Analyses To Diagnosis And Treatment In The Mental Disorders.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2019Article
- Dynamic changes of functional segregation and integration in vulnerability and resilience to schizophrenia.Human brain mapping · 2019Article
- Shared Genetic Risk of Schizophrenia and Gray Matter Reduction in 6p22.1.Schizophrenia bulletin · 2019Article
- A Schizophrenia-Related Genetic-Brain-Cognition Pathway Revealed in a Large Chinese Population.EBioMedicine · 2018Article
- Characterization of cross-tissue genetic-epigenetic effects and their patterns in schizophrenia.Genome medicine · 2018Article
- Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.Frontiers in psychiatry · 2018Article
- A Perspective of the Cross-Tissue Interplay of Genetics, Epigenetics, and Transcriptomics, and Their Relation to Brain Based Phenotypes in Schizophrenia.Frontiers in genetics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 9 institutions in 3 countries.
Funding
Abstract
Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter (GM) measures to explore the role of genetic and epigenetic variation to the brain structure changes in schizophrenia (SZ). By focusing on the reported SZ genetic risk regions, we applied a multi-stage multivariate analysis to a discovery dataset (92 SZ patients and 110 controls, blood) and an independent replication dataset (93 SZ patients and 99 controls, saliva). Two pairs of SNP-methylation components were significantly correlated (r = .48 and .35) in blood DNA, and replicated (r = .46 and .29) in saliva DNA, reflecting cross-tissue SNP cis-effects. In the discovery data, both SNP-related methylation components were also associated with one GM component primarily located in cerebellum, caudate, and thalamus. Additionally, another methylation component in NOSIP gene with significant SZ patient differences (P = .009), was associated with 8 GM components (7 with patient differences) including superior, middle, and inferior frontal gyri, superior, middle, and inferior temporal gyri, cerebellum, insula, cuneus, and lingual gyrus. Of these, 5 methylation-GM associations were replicated (P < .05). In contrast, no pairwise significant associations were observed between SNP and GM components. This study strongly supports that compared to genetic variation, epigenetics show broader and more significant associations with brain structure as well as diagnosis, which can be cross-tissue, and the potential in explaining the mechanism of genetic risks in SZ.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.