Evidence map›Paper›PMID 28526298›Full record

ArticleThe Journal of investigative dermatology2017

Regulation of the Glycerol Transporter, Aquaporin-3, by Histone Deacetylase-3 and p53 in Keratinocytes.

Vivek Choudhary, Lawrence O Olala, Karen Kagha, Zhi-Qiang Pan, Xunsheng Chen, Rong Yang, Abigail Cline, Inas Helwa, Lauren Marshall, Ismail Kaddour-Djebbar and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Aquaporin-3 in the epidermis: more than skin deep.American journal of physiology. Cell physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Vivek ChoudharyCharlie Norwood VA Medical Center, Augusta, Georgia, USA; Department of Physiology, Augusta University, Augusta, Georgia, USA; Department of Medicine (Dermatology), Augusta University, Augusta, Georgia, USA. Electronic address: vchoudhary@augusta.edu.
Lawrence O OlalaCharlie Norwood VA Medical Center, Augusta, Georgia, USA; Department of Physiology, Augusta University, Augusta, Georgia, USA.
Karen KaghaDepartment of Physiology, Augusta University, Augusta, Georgia, USA.
Zhi-Qiang PanDepartment of Physiology, Augusta University, Augusta, Georgia, USA; School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xunsheng ChenCharlie Norwood VA Medical Center, Augusta, Georgia, USA; Department of Physiology, Augusta University, Augusta, Georgia, USA.
Rong YangDepartment of Physiology, Augusta University, Augusta, Georgia, USA; Department of Physiology, Medical School, Jianghan University, Wuhan, China.
Abigail ClineDepartment of Physiology, Augusta University, Augusta, Georgia, USA.
Inas HelwaDepartment of Physiology, Augusta University, Augusta, Georgia, USA; Department of Oral Biology, Augusta University, Augusta, Georgia, USA.
Lauren MarshallDepartment of Physiology, Augusta University, Augusta, Georgia, USA.
Ismail Kaddour-DjebbarCharlie Norwood VA Medical Center, Augusta, Georgia, USA; Department of Physiology, Augusta University, Augusta, Georgia, USA.
Meghan E McGee-LawrenceDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, Georgia, USA.
Wendy B BollagCharlie Norwood VA Medical Center, Augusta, Georgia, USA; Department of Physiology, Augusta University, Augusta, Georgia, USA; Department of Medicine (Dermatology), Augusta University, Augusta, Georgia, USA; Department of Oral Biology, Augusta University, Augusta, Georgia, USA.
Augusta University · USCharlie Norwood VA Medical Center · USShanghai University of Traditional Chinese Medicine · CN

Funding

Epidermal Aquaporin-3 in PsoriasisI01CX001357 · VA · CHARLIE NORWOOD VA MEDICAL CENTER · PI BOLLAG, WENDY B · 2016 to 2020
–
CSRD VA I01 CX001357
6 · The paper itself

Abstract

Aquaporin- (AQP) 3, a water and glycerol channel, plays an important role in epidermal function, with studies showing its involvement in keratinocyte proliferation, differentiation, and migration and in epidermal wound healing and barrier repair. Increasing speculation about the use of histone deacetylase (HDAC) inhibitors to treat skin diseases led us to investigate HDAC's role in the regulation of AQP3. The broad-spectrum HDAC inhibitor suberoylanilide hydroxamic acid induced AQP3 mRNA and protein expression in a dose- and time-dependent manner in normal keratinocytes. The SAHA-induced increase in AQP3 levels resulted in enhanced [

Indexed as

AnimalsAnimals, NewbornAquaporin 3Biological TransportCell DifferentiationCell ProliferationCells, CulturedEpidermisGlycerolHistone Deacetylase 3Histone DeacetylasesHumansIn Vitro TechniquesKeratinocytesMiceMice, KnockoutAquaporin 3GlycerolHistone Deacetylase 3Histone DeacetylasesTumor Suppressor Protein p53

Identifiers

PMID28526298
PMCPMC6733407
OpenAlexW2614567437

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.