Evidence map›Paper›PMID 28528988›Full record

ReviewTrends in cell biology2017

Ubiquitin-Dependent Regulation of Stem Cell Biology.

Achim Werner, Andrew G Manford, Michael Rape

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Achim WernerDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Andrew G ManfordDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Michael RapeDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: mrape@berkeley.edu.

Funding

Dissecting Mechanisms of Ubiquitination and Deubiquitination in Cell Cycle ControR01GM083064 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAPE, MICHAEL P · 2008 to 2016
$2.2M
Ubiquitin-dependent regulation of ribosome function in cell fate determinationK99DE025314 · NIDCR · UNIVERSITY OF CALIFORNIA BERKELEY · PI WERNER, ACHIM · 2015 to 2016
$245k
Howard Hughes Medical InstituteNIDCR NIH HHS K99 DE025314NIGMS NIH HHS R01 GM083064
6 · The paper itself

Abstract

The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions by stem cells which can undergo self-renewal, reversibly enter a quiescent state, or terminally commit to a cell specification program. To guide their decisions, stem cells make frequent use of ubiquitylation, a post-translational modification that can affect the activity, interaction landscape, or stability of stem cell proteins. In this review we discuss novel findings that have provided insight into ubiquitin-dependent mechanisms of stem cell control and revealed how an essential and highly conserved protein modification can shape metazoan development.

Indexed as

Protein Processing, Post-TranslationalUbiquitinationAnimalsCell DifferentiationCell DivisionCell Self RenewalHumansStem CellsUbiquitinUbiquitin-Protein LigasesUbiquitinUbiquitin-Protein LigasesdevelopmentdifferentiationE3 ligasestem cellubiquitin

Identifiers

PMID28528988
PMCPMC5643009

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.