Evidence map›Paper›PMID 28533328›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Tendon stem/progenitor cells regulate inflammation in tendon healing

Solaiman Tarafder, Esther Chen, Yena Jun, Kristy Kao, Kun Hee Sim, Jungho Back, Francis Y Lee, Chang H Lee

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 120 citations in OpenAlex.

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  14. CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Aging and injury affect nuclear shape heterogeneity in tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  19. Tppp3Bone research · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Solaiman TarafderRegenerative Engineering Laboratory, Columbia University Irving Medical Center, New York, New York, USA.
Esther ChenRegenerative Engineering Laboratory, Columbia University Irving Medical Center, New York, New York, USA.
Yena JunRegenerative Engineering Laboratory, Columbia University Irving Medical Center, New York, New York, USA.
Kristy KaoRegenerative Engineering Laboratory, Columbia University Irving Medical Center, New York, New York, USA.
Kun Hee SimRegenerative Engineering Laboratory, Columbia University Irving Medical Center, New York, New York, USA.
Jungho BackDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA.
Francis Y LeeDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA.
Chang H LeeRegenerative Engineering Laboratory, Columbia University Irving Medical Center, New York, New York, USA; chl2109@cumc.columbia.edu.
Columbia University Irving Medical Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TMJ Disc Regeneration by 3D-Printed Bioscaffolds in a Pre-Clinical Animal ModelR03DE026794 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEE, CHANG HUN · 2017 to 2018
$240k
NCATS NIH HHS UL1 TR001863NIDCR NIH HHS R03 DE026794
6 · The paper itself

Abstract

Tendon stem/progenitor cells (TSCs) have been found in different anatomic locations and showed a promising regenerative potential. We identified a role of TSCs in the regulation of inflammation during healing of acute tendon injuries. Delivery of connective tissue growth factor (CTGF) into full-transected rat patellar tendons significantly increased the number of CD146

Indexed as

AnimalsConnective Tissue Growth FactorCytokinesGene Expression RegulationInflammationMAP Kinase Kinase 4RatsRats, Sprague-DawleySignal TransductionSTAT3 Transcription FactorStem CellsTendon InjuriesTendonsTissue Inhibitor of Metalloproteinase-3CCN2 protein, ratConnective Tissue Growth FactorCytokinesMAP Kinase Kinase 4Stat3 protein, ratSTAT3 Transcription FactorTissue Inhibitor of Metalloproteinase-3CD146CTGFTSC

Identifiers

PMID28533328
PMCPMC5572690
OpenAlexW2619375165

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.