Evidence map›Paper›PMID 28536097›Full record

ArticleDevelopment (Cambridge, England)2017

Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network.

Jason E Fish, Manuel Cantu Gutierrez, Lan T Dang, Nadiya Khyzha, Zhiqi Chen, Shawn Veitch, Henry S Cheng, Melvin Khor, Lina Antounians, Makon-Sébastien Njock and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 98 citations in OpenAlex.

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  16. Single cell 'omic profiles of human aortic endothelial cellsbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Transcription factors regulating vasculogenesis and angiogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Jason E FishToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada wythe@bcm.edu jason.fish@utoronto.ca.
Manuel Cantu GutierrezCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Lan T DangToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Nadiya KhyzhaToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Zhiqi ChenToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Shawn VeitchToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Henry S ChengToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Melvin KhorToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Lina AntouniansGenetics and Genome Biology, Hospital for Sick Children, Toronto M5G 0A4, Canada.
Makon-Sébastien NjockToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Emilie BoudreauToronto General Hospital Research Institute, University Health Network, Toronto M5G 2C4, Canada.
Alexander M HermanCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Alexander M RhynerCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Oscar E RuizDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
George T EisenhofferGraduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Alejandra Medina-RiveraGenetics and Genome Biology, Hospital for Sick Children, Toronto M5G 0A4, Canada.
Michael D WilsonHeart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto M5S 3H2, Canada.
Joshua D WytheCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA wythe@bcm.edu jason.fish@utoronto.ca.ORCID 0000-0002-3225-2937
University Health Network · CABaylor College of Medicine · USThe University of Texas MD Anderson Cancer Center · USUniversity of Toronto · CAHospital for Sick Children · CA

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael T. Lewis · 2007 to 2026
$73.9M
Molecular Physiology of the Cardiovascular SystemT32HL007676 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L · 1989 to 2020
$7.9M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NHLBI NIH HHS T32 HL007676
6 · The paper itself

Abstract

The transcriptional pathways activated downstream of vascular endothelial growth factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand delta-like 4 (DLL4) in endothelial cells, we find that activation of the MAPK/ERK pathway mirrors the rapid and dynamic induction of

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCalcium-Binding ProteinsCattleE1A-Associated p300 ProteinEnhancer Elements, GeneticExtracellular Signal-Regulated MAP KinasesFemaleGene Expression RegulationGene Expression Regulation, DevelopmentalGene Regulatory NetworksHumansHuman Umbilical Vein Endothelial CellsIntercellular Signaling Peptides and ProteinsIntronsMaleAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsDLL4 protein, humanE1A-Associated p300 ProteinEP300 protein, humanERG protein, humanExtracellular Signal-Regulated MAP KinasesIntercellular Signaling Peptides and ProteinsTranscriptional Regulator ERGVascular Endothelial Growth Factor AAngiogenesisEndothelial cellEnhancerETS factorGenome editingHumanMouseTranscriptionZebrafish

Identifiers

PMID28536097
PMCPMC5536864
OpenAlexW2617220693

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.