Evidence map›Paper›PMID 28539432›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate.

Cheryl M Hanes, Anna E D'Amico, Takehiko Ueyama, Alexander C Wong, Xuexin Zhang, W Frederick Hynes, Margarida M Barroso, Nathaniel C Cady, Mohamed Trebak, Naoaki Saito and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Identification of Myeloid Protein Kinase C Epsilon as a Novel Atheroprotective Gene.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  2. Article
  3. TheFrontiers in cellular and infection microbiology · 2021
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Cheryl M HanesDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208.ORCID 0000-0003-1131-7532
Anna E D'AmicoDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208.
Takehiko UeyamaBiosignal Research Center, Kobe University, Kobe 657-8501, Japan.ORCID 0000-0002-5647-3937
Alexander C WongDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208.
Xuexin ZhangDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033.
W Frederick HynesCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203; and.
Margarida M BarrosoDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208.
Nathaniel C CadyCollege of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203; and.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033.ORCID 0000-0001-6759-864X
Naoaki SaitoBiosignal Research Center, Kobe University, Kobe 657-8501, Japan.ORCID 0000-0003-3389-1367
Michelle R LennartzDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208; lennarm@mail.amc.edu.
Albany Medical Center Hospital · USKobe University · JPPennsylvania State University · USSUNY Polytechnic Institute · US

Funding

Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
Protein Kinase C in Macrophage ActivationR01AI050821 · NIAID · ALBANY MEDICAL COLLEGE · PI LENNARTZ, MICHELLE R · 2002 to 2006
$1.6M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
Role of Protein Kinase C in Macrophage ActivationR01GM090325 · NIGMS · ALBANY MEDICAL COLLEGE · PI LENNARTZ, MICHELLE R · 2009 to 2012
$1.3M
NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NIAID NIH HHS R01 AI050821NIGMS NIH HHS R01 GM090325
6 · The paper itself

Abstract

Protein kinase C-ε (PKC-ε) at phagocytic cups mediates the membrane fusion necessary for efficient IgG-mediated phagocytosis. The C1B and pseudosubstrate (εPS) domains are necessary and sufficient for this concentration. C1B binds diacylglycerol; the docking partner for εPS is unknown. Liposome assays revealed that the εPS binds phosphatidylinositol 4-phosphate (PI4P) and PI(3,5)P

Indexed as

PhagocytosisAnimalsCell MembraneGolgi ApparatusGreen Fluorescent ProteinsMembrane FusionMicePeptide FragmentsPhagosomesPhosphatidylinositol PhosphatesProtein Kinase CProtein Kinase C-epsilonSignal TransductionGreen Fluorescent ProteinsPeptide Fragmentsphosphatidylinositol 4-phosphatePhosphatidylinositol PhosphatesProtein Kinase CProtein Kinase C-epsilonprotein kinase C gamma (101-112)

Identifiers

PMID28539432
PMCPMC5505341
OpenAlexW2620190783

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.