Evidence map›Paper›PMID 28539604›Full record

ArticleScientific reports2017

Prostaglandin E

Antje Brüser, Anne Zimmermann, Brenda C Crews, Gregory Sliwoski, Jens Meiler, Gabriele M König, Evi Kostenis, Vera Lede, Lawrence J Marnett, Torsten Schöneberg

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Inflammation and cancer: friend or foe?Frontiers in pharmacology · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Mechanisms of pain in sickle cell disease.British journal of pain · 2021
    Article
  9. Article
  10. Update of P2Y receptor pharmacology: IUPHAR Review 27.British journal of pharmacology · 2020
    Review
  11. Druggable Targets in Endocannabinoid Signaling.Advances in experimental medicine and biology · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Antje BrüserRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany. antje.brueser@medizin.uni-leipzig.de.
Anne ZimmermannRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany.
Brenda C CrewsDepartment of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232-0146, USA.
Gregory SliwoskiDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, 37232-8725, USA.
Jens MeilerDepartment of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN, 37232-8725, USA.
Gabriele M KönigInstitute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany.
Evi KostenisInstitute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany.
Vera LedeRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany.
Lawrence J MarnettDepartment of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232-0146, USA.
Torsten SchönebergRudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany. schoberg@medizin.uni-leipzig.de.
Leipzig University · DEVanderbilt University · USUniversity of Bonn · DE

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Biomedical Informatics Training ProgramT15LM007450 · NLM · VANDERBILT UNIVERSITY · PI Jessica S. Ancker, Bradley A. Malin · 2002 to 2026
$19.7M
THE PHARMACOLOGY OF INHIBITORS OF HEME PROTEIN-CATALYZED LIPID PEROXIDATIONP50GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 1985 to 2010
$15.0M
Therapeutic Modulation of Endothelial Cell TetrahydrobiopterinP01GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2011 to 2015
$9.5M
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
NIDDK NIH HHS P30 DK058404NIGMS NIH HHS P01 GM015431NIGMS NIH HHS P50 GM015431NLM NIH HHS T15 LM007450
6 · The paper itself

Abstract

Cyclooxygenase-2 catalyses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol. Previous studies identified PG-Gs as signalling molecules involved in inflammation. Thus, the glyceryl ester of prostaglandin E

Indexed as

TranscriptomeAnimalsBinding SitesCell Line, TumorCyclooxygenase 2DinoprostoneHEK293 CellsHigh-Throughput Nucleotide SequencingHigh-Throughput Screening AssaysHumansKineticsLigandsMiceMolecular Docking SimulationProtein BindingProtein Conformation, alpha-HelicalCyclooxygenase 2DinoprostoneLigandsprostaglandin E2 glyceryl esterPurinergic Agonistspurinoceptor P2Y6Receptors, Purinergic P2

Identifiers

PMID28539604
PMCPMC5443783
OpenAlexW2616020608

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.