ArticleAddiction (Abingdon, England)2017
Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood.
Article in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- The Longitudinal Impact of Discrimination on Substance Use among Filipino and Korean American Youth.Journal of racial and ethnic health disparities · 2026Article
- Positive face BOLD response and task-dependent ventral striatal functional connectivity during Go/No-go task among abstinent cannabis-using adolescents and young adults.Frontiers in adolescent medicine · 2026Article
- Adolescent substance use trajectories are associated with nucleus accumbens functional connectivity.Journal of psychopharmacology (Oxford, England) · 2025Article
- Cannabis use in adolescence and young adulthood and its effects on brain structure and function: a scoping review.Frontiers in psychiatry · 2025Review
- Should Marijuana Be Legalized: A Scoping Review of Associations of Marijuana and Depression.Cureus · 2023Article
- Neural responses to reward anticipation and feedback in adult and adolescent cannabis users and controls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Functional brain connectomes reflect acute and chronic cannabis use.Scientific reports · 2022Article
- Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood.Frontiers in human neuroscience · 2022Article
- Neural and behavioral correlates associated with adolescent marijuana use.Current addiction reports · 2020Article
- Cannabis and the Developing Adolescent Brain.Current treatment options in psychiatry · 2020Article
- Review
- Post-trauma anhedonia is associated with increased substance use in a recently-traumatized population.Psychiatry research · 2020Article
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- Does Chronic Cannabis Use Impact Risky Decision-Making: An Examination of fMRI Activation and Effective Connectivity?Frontiers in psychiatry · 2020Article
- Effects of Adolescent Cannabis Use on Motivation and Depression: A Systematic Review.Current addiction reports · 2019Article
- Behavioral Treatments for Adolescent Cannabis Use Disorder: a Rationale for Cognitive Retraining.Current addiction reports · 2019Article
- Cannabis and the developing brain: What does the evidence say?Birth defects research · 2019Review
- The neuropsychopharmacology of cannabis: A review of human imaging studies.Pharmacology & therapeutics · 2019Review
Corrections and comments
- Commented on by
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aims(1) To identify trajectories of cannabis use across adolescence, (2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc) and (3) to assess whether patterns of functional connectivity related to cannabis use are associated with psychosocial functioning 2 years later.
designThe Pitt Mother and Child Project (PMCP) is a prospective, longitudinal study of male youth at high risk for psychopathology based on family income and gender.
settingParticipants were recruited between age 6 and 17 months from the Women, Infants and Children Nutritional Supplement program (WIC) in the Pittsburgh, Pennsylvania area.
participantsA total of 158 PMCP young men contributed functional magnetic resonance imaging (fMRI) and substance use data at age 20 years. MEASUREMENTS: Latent class growth analysis was used to determine trajectories of cannabis use frequency from age 14 to 19 years. Psychophysiological interaction (PPI) analysis was used to measure functional connectivity between the NAcc and prefrontal cortex (PFC). Adolescent cannabis use trajectory, recent frequency of use and age of initiation were considered as developmental factors. We also tested whether functional connectivity was associated with depressive symptoms, anhedonia and educational attainment at age 22.
findingsWe identified three distinct trajectories of adolescent cannabis use, characterized by stable high, escalating or stable low use. The cannabis use trajectory group had a significant effect on NAcc functional connectivity to the medial PFC (F = 11.32, Z = 4.04, P
conclusionsPattern of cannabis use frequency across adolescence in US youth could have consequences for mood symptoms and educational attainment in early adulthood via altered function in neural reward circuitry.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.