ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
The Gliotransmitter d-Serine Promotes Synapse Maturation and Axonal Stabilization
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Protocol for blastomere injection to generate bilateral hemimosaic Xenopus tadpoles.STAR protocols · 2026Article
- Glial D-serine modulates oligodendrocyte lineage progression under inflammatory conditions.Frontiers in cellular neuroscience · 2026Article
- Parallel Morphological and Functional Development in the Xenopus Retinotectal System.Developmental neurobiology · 2026Article
- Detection and functional assessment of D-amino acids as potential biomarkers in neurological disorders.Molecular biology reports · 2025Review
- An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems.Nature communications · 2025Article
- Mutations in PTPN11 could lead to a congenital myasthenic syndrome phenotype: a Noonan syndrome case series.Journal of neurology · 2024Article
- Capturing a rising star: the emerging role of astrocytes in neural circuit wiring and plasticity-lessons from the visual system.Neurophotonics · 2023Review
- The effects of the NMDAR co-agonist D-serine on the structure and function of optic tectal neurons in the developing visual system.Scientific reports · 2023Article
- Glia Regulate the Development, Function, and Plasticity of the Visual System From Retina to Cortex.Frontiers in neural circuits · 2022Review
- The connection between innervation and metabolic rearrangements in pancreatic cancer through serine.Frontiers in oncology · 2022Review
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Electrophysiological Recording for Study ofCold Spring Harbor protocols · 2021Article
- From Neural Tube Formation Through the Differentiation of Spinal Cord Neurons: Ion Channels in Action During Neural Development.Frontiers in molecular neuroscience · 2020Article
- Article
- Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing.Developmental neurobiology · 2018Article
- Optical Probes for Neurobiological Sensing and Imaging.Accounts of chemical research · 2018Review
- Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease.Frontiers in cellular neuroscience · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NMDAR is thought to play a key role in the refinement of connectivity in developing neural circuits. Pharmacological blockade or genetic loss-of-function manipulations that prevent NMDAR function during development result in the disorganization of topographic axonal projections. However, because NMDARs contribute to overall glutamatergic neurotransmission, such loss-of-function experiments fail to adequately distinguish between the roles played by NMDARs and neural activity in general. The gliotransmitter d-serine is a coagonist of the NMDAR that is required for NMDAR channel opening, but which cannot mediate neurotransmission on its own. Here we demonstrate that acute administration of d-serine has no immediate effect on glutamate release or AMPA-mediated neurotransmission. We show that endogenous d-serine is normally present below saturating levels in the developing visual system of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.