Evidence map›Paper›PMID 28559488›Full record

ArticlemBio2017

Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter.

Xiaohong Wang, Haibin Liu, Hui Ge, Masahiko Ajiro, Nishi R Sharma, Craig Meyers, Pavel Morozov, Thomas Tuschl, Amar Klar, Donald Court and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Xiaohong WangRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Haibin LiuRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Hui GeAscentGene, Inc., Gaithersburg, Maryland, USA.
Masahiko AjiroRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Nishi R SharmaRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Craig MeyersDepartment of Microbiology and Immunology, Penn State University College of Medicine, Hershey, Pennsylvania, USA.
Pavel MorozovHoward Hughes Medical Institute and Laboratory of RNA Molecular Biology, Rockefeller University, New York, New York, USA.
Thomas TuschlHoward Hughes Medical Institute and Laboratory of RNA Molecular Biology, Rockefeller University, New York, New York, USA.
Amar KlarRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Donald CourtRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Zhi-Ming ZhengRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA zhengt@exchange.nih.gov.
Center for Cancer Research · USNational Cancer Institute · USHoward Hughes Medical Institute · USNational Institutes of Health · USPennsylvania State University · USRockefeller University · US

Funding

Gene Expression and Post-Transcriptional Regulation of DNA Tumor VirusesZIASC010357 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI ZHENG, ZHI-MING · 2009 to 2025
$24.3M
6 · The paper itself

Abstract

The life cycle of human papillomaviruses (HPVs) is tightly linked to keratinocyte differentiation. Although expression of viral early genes is initiated immediately upon virus infection of undifferentiated basal cells, viral DNA amplification and late gene expression occur only in the mid to upper strata of the keratinocytes undergoing terminal differentiation. In this report, we show that the relative activity of HPV18 TATA-less late promoter P

Indexed as

Promoter Regions, GeneticTranscription, GeneticAphidicolinDNA ReplicationDNA, ViralGene Expression Regulation, ViralGenes, ViralHeterogeneous-Nuclear RibonucleoproteinsHost-Pathogen InteractionsHuman papillomavirus 18HumansKeratinocytesReplication OriginRNA SplicingVirus ReplicationAphidicolinDNA, ViralHeterogeneous-Nuclear RibonucleoproteinsDNA replicationgene expressionHPV18human papillomavirusespromoterssmall RNAstranscriptiontranscriptional regulation

Identifiers

PMID28559488
PMCPMC5449659
OpenAlexW2620310009

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.