Evidence map›Paper›PMID 28560832›Full record

Trial reportJournal of sleep research2017

Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes.

Ari Shechter, Gary D Foster, Wei Lang, David M Reboussin, Marie-Pierre St-Onge, Gary Zammit, Anne B Newman, Richard P Millman, Thomas A Wadden, John M Jakicic and 5 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of sleep research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  2. Trial
  3. Review
  4. REM sleep obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Ari ShechterCenter for Behavioral Cardiovascular Health, Department of Medicine, Columbia University, New York, NY, USA.
Gary D FosterCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Wei LangDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
David M ReboussinDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Marie-Pierre St-OngeNew York Obesity Nutrition Research Center, Department of Medicine, Columbia University, New York, NY, USA.
Gary ZammitClinilabs, New York, NY, USA.
Anne B NewmanCenter for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Richard P MillmanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Thomas A WaddenCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
John M JakicicPhysical Activity and Weight Management Research Center, Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA, USA.
Elsa S StrotmeyerCenter for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Rena R WingDepartment of Psychiatry and Human Behavior, Weight Control and Diabetes Research Center, The Miriam Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
F Xavier Pi-SunyerNew York Obesity Nutrition Research Center, Department of Medicine, Columbia University, New York, NY, USA.
Samuel T KunaDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sleep Ahead Research Group of the Look Ahead Research Group
University of Pennsylvania · USUniversity of Pittsburgh · USColumbia University · USWake Forest University · USBrown University · USClinilabs (United States) · USColumbia University Irving Medical Center · USMiriam Hospital · US

Funding

STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057135 · UNIVERSITY OF PENNSYLVANIA · 1999 to 2005
$8.2M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW) TRIALU01DK056992 · MIRIAM HOSPITAL · 1999 to 2005
$8.1M
RESEARCH TRAININGP30DK026687 · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · 1986 to 2025
$7.5M
Sleep Apnea in Look AHEAD ParticipantsR01HL070301 · UNIVERSITY OF PENNSYLVANIA · 2001 to 2005
$2.7M
The Identification of Modifiable Emergency Department and Sleep Factors Contributing to Psychological and Cardiovascular Risk in CliniciansR01HL146911 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Bernard P. Chang, Ari Shechter · 2022 to 2024
$2.3M
OBESITY RESEARCH CENTER TRAINING PROGRAMT32DK007559 · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · 1989 to 2025
$1.7M
NHLBI NIH HHS L30 HL115420NHLBI NIH HHS R01 HL070301NHLBI NIH HHS R01 HL146911NIDDK NIH HHS P30 DK026687NIDDK NIH HHS T32 DK007559NIDDK NIH HHS U01 DK056992NIDDK NIH HHS U01 DK057135
6 · The paper itself

Abstract

The aim of this study was to determine if an intensive lifestyle intervention (ILI) reduces the severity of obstructive sleep apnea (OSA) in rapid-eye movement (REM) sleep, and to determine if longitudinal changes in glycaemic control are related to changes in OSA severity during REM sleep over a 4-year follow-up. This was a randomized controlled trial including 264 overweight/obese adults with type 2 diabetes (T2D) and OSA. Participants were randomized to an ILI targeted to weight loss or a diabetes support and education (DSE) control group. Measures included anthropometry, apnea-hypopnea index (AHI) during REM sleep (REM-AHI) and non-REM sleep (NREM-AHI) and glycated haemoglobin (HbA1c) at baseline and year 1, year 2 and year 4 follow-ups. Mean baseline values of REM-AHI were significantly higher than NREM-AHI in both groups. Both REM-AHI and NREM-AHI were reduced significantly more in ILI versus DSE, but these differences were attenuated slightly after adjustment for weight changes. Repeated-measure mixed-model analyses including data to year 4 demonstrated that changes in HbA1c were related significantly to changes in weight, but not to changes in REM-AHI and NREM-AHI. Compared to control, the ILI reduced REM-AHI and NREM-AHI during the 4-year follow-up. Weight, as opposed to REM-AHI and NREM-AHI, was related to changes in HbA1c. The findings imply that weight loss from a lifestyle intervention is more important than reductions in AHI for improving glycaemic control in T2D patients with OSA.

Indexed as

Life StyleSleep, REMWeight LossAgedAnthropometryBlood GlucoseDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlycated HemoglobinHumansMaleMiddle AgedObesityOverweightPolysomnographyBlood GlucoseGlycated HemoglobinHbA1cobesityobstructive sleep apneaREM sleeptype 2 diabetes

Identifiers

PMID28560832
PMCPMC5705337
OpenAlexW2618798482

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.