Evidence map›Paper›PMID 28577489›Full record

ReviewRedox biology2017

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Javier Egea, Isabel Fabregat, Yves M Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G Knaus, Manuela G Lopez, Gloria Olaso-Gonzalez and 141 more

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 138 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 1 synthesis or guideline pooled it, 316 citations in OpenAlex.

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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

151 authors at 20 institutions in 29 countries.

Javier EgeaInstitute Teofilo Hernando, Department of Pharmacology, School of Medicine. Univerisdad Autonoma de Madrid, Spain.
Isabel FabregatBellvitge Biomedical Research Institute (IDIBELL) and University of Barcelona (UB), L'Hospitalet, Barcelona, Spain.
Yves M FrapartLCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Pietro GhezziBrighton & Sussex Medical School, Brighton, UK.
Agnes GörlachExperimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Thomas KietzmannFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, Oulu, Finland.
Kateryna KubaichukFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, Oulu, Finland.
Ulla G KnausConway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Manuela G LopezInstitute Teofilo Hernando, Department of Pharmacology, School of Medicine. Univerisdad Autonoma de Madrid, Spain.
Gloria Olaso-GonzalezDepartment of Physiology, University of Valencia, Spain.
Andreas PetryExperimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany.
Rainer SchulzInstitute of Physiology, JLU Giessen, Giessen, Germany.
Jose VinaDepartment of Physiology, University of Valencia, Spain.
Paul WinyardUniversity of Exeter Medical School, St Luke's Campus, Exeter EX1 2LU, UK.
Kahina AbbasLCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Opeyemi S AdemowoLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Catarina B AfonsoSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Ioanna AndreadouLaboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
Haike AntelmannInstitute for Biology-Microbiology, Freie Universität Berlin, Berlin, Germany.
Fernando AntunesDepartamento de Química e Bioquímica and Centro de Química e Bioquímica, Faculdade de Ciências, Portugal.
Mutay AslanDepartment of Medical Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Markus M BachschmidVascular Biology Section & Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Rui M BarbosaCenter for Neurosciences and Cell Biology, University of Coimbra and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Vsevolod BelousovMolecular technologies laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow 117997, Russia.
Carsten BerndtDepartment of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
David BernlohrDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota - Twin Cities, USA.
Esther BertránBellvitge Biomedical Research Institute (IDIBELL) and University of Barcelona (UB), L'Hospitalet, Barcelona, Spain.
Alberto BindoliInstitute of Neuroscience (CNR), Padova, Italy.
Serge P BottariGETI, Institute for Advanced Biosciences, INSERM U1029, CNRS UMR 5309, Grenoble-Alpes University and Radio-analysis Laboratory, CHU de Grenoble, Grenoble, France.
Paula M BritoResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal; Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
Guia CarraraDepartment of Pathology, University of Cambridge, Cambridge, UK.
Ana I CasasDepartment of Pharmacology & Personalized Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Afroditi ChatziInstitute of Molecular Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow, UK.
Niki ChondrogianniNational Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
Marcus ConradHelmholtz Center Munich, Institute of Developmental Genetics, Neuherberg, Germany.
Marcus S CookeOxidative Stress Group, Dept. Environmental & Occupational Health, Florida International University, Miami, FL 33199, USA.
João G CostaResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal; CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
Antonio CuadradoInstituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Instituto de Investigación Sanitaria La Paz (IdiPaz), Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Pham My-Chan DangUniversité Paris Diderot, Sorbonne Paris Cité, INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.
Barbara De SmetDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Structural Biology Research Center, VIB, 1050 Brussels, Belgium; Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy; Pharmahungary Group, Szeged, Hungary.
Bilge Debelec-ButunerDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Bornova, Izmir 35100, Turkey.
Irundika H K DiasLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Joe Dan DunnDepartment of Biochemistry, Science II, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva-4, Switzerland.
Amanda J EdsonDepartment of Molecular Biology, University of Bergen, Bergen, Norway.
Mariam El AssarFundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.
Jamel El-BennaUniversité Paris Diderot, Sorbonne Paris Cité, INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.
Péter FerdinandyDepartment of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
Ana S FernandesCBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
Kari E FladmarkDepartment of Molecular Biology, University of Bergen, Bergen, Norway.
Ulrich FörstermannDepartment of Pharmacology, Johannes Gutenberg University Medical Center, Mainz, Germany.
Rashid GiniatullinA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Zoltán GiriczDepartment of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
Anikó GörbeDepartment of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
Helen GriffithsLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK; Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Vaclav HamplDepartment of Physiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Alina HanfMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Jan HergetDepartment of Physiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Pablo Hernansanz-AgustínServicio de Immunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas Alberto Sols, Madrid, Spain.
Melanie HillionInstitute for Biology-Microbiology, Freie Universität Berlin, Berlin, Germany.
Jingjing HuangDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Structural Biology Research Center, VIB, 1050 Brussels, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Serap IlikayHarran University, Arts and Science Faculty, Department of Biology, Cancer Biology Lab, Osmanbey Campus, Sanliurfa, Turkey.
Pidder Jansen-DürrInstitute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
Vincent JaquetDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Jaap A JolesDepartment of Nephrology & Hypertension, University Medical Center Utrecht, The Netherlands.
Balaraman KalyanaramanMedical College of Wisconsin, Milwaukee, USA.
Danylo KaminskyyDanylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Mahsa KarbaschiOxidative Stress Group, Dept. Environmental & Occupational Health, Florida International University, Miami, FL 33199, USA.
Marina KleanthousMolecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Lars-Oliver KlotzInstitute of Nutrition, Department of Nutrigenomics, Friedrich Schiller University, Jena, Germany.
Bato KoracUniversity of Belgrade, Institute for Biological Research "Sinisa Stankovic" and Faculty of Biology, Belgrade, Serbia.
Kemal Sami KorkmazDepartment of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering, Ege University, Bornova, 35100 Izmir, Turkey.
Rafal KozielInstitute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
Damir KračunExperimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany.
Karl-Heinz KrauseDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Vladimír KřenInstitute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences, Videnska 1083, CZ-142 20 Prague, Czech Republic.
Thomas KriegDepartment of Medicine, University of Cambridge, UK.
João LaranjinhaCenter for Neurosciences and Cell Biology, University of Coimbra and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Antigone LazouSchool of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Huige LiDepartment of Pharmacology, Johannes Gutenberg University Medical Center, Mainz, Germany.
Antonio Martínez-RuizServicio de Immunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Reiko MatsuiVascular Biology Section & Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Gethin J McBeanSchool of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.
Stuart P MeredithSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Joris MessensStructural Biology Research Center, VIB, 1050 Brussels, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Verónica MiguelCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Madrid, Spain.
Yuliya MikhedMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Irina MilisavUniversity of Ljubljana, Faculty of Medicine, Institute of Pathophysiology and Faculty of Health Sciences, Ljubljana, Slovenia.
Lidija MilkovićRuđer Bošković Institute, Division of Molecular Medicine, Zagreb, Croatia.
Antonio Miranda-VizueteInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Miloš MojovićUniversity of Belgrade, Faculty of Physical Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
María MonsalveInstituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.
Pierre-Alexis MouthuyLaboratory for Oxidative Stress, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
John MulveyDepartment of Medicine, University of Cambridge, UK.
Thomas MünzelMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Vladimir MuzykantovDepartment of Pharmacology, Center for Targeted Therapeutics & Translational Nanomedicine, ITMAT/CTSA Translational Research Center University of Pennsylvania The Perelman School of Medicine, Philadelphia, PA, USA.
Isabel T N NguyenDepartment of Nephrology & Hypertension, University Medical Center Utrecht, The Netherlands.
Matthias OelzeMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Nuno G OliveiraResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.
Carlos M PalmeiraCenter for Neurosciences & Cell Biology of the University of Coimbra, Coimbra, Portugal; Department of Life Sciences of the Faculty of Sciences & Technology of the University of Coimbra, Coimbra, Portugal.
Nikoletta PapaevgeniouNational Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
Aleksandra PavićevićUniversity of Belgrade, Faculty of Physical Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Brandán PedreStructural Biology Research Center, VIB, 1050 Brussels, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Fabienne PeyrotLCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France; ESPE of Paris, Paris Sorbonne University, Paris, France.
Marios PhylactidesMolecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Gratiela G PircalabioruThe Research Institute of University of Bucharest, Bucharest, Romania.
Andrew R PittSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Henrik E PoulsenLaboratory of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark; Department of Clinical Pharmacology, Bispebjerg Frederiksberg Hospital, University Hospital Copenhagen, Denmark; Department Q7642, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Ignacio PrietoInstituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.
Maria Pia RigobelloDepartment of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, 35131 Padova, Italy.
Natalia Robledinos-AntónInstituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Instituto de Investigación Sanitaria La Paz (IdiPaz), Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Leocadio Rodríguez-MañasFundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain; Servicio de Geriatría, Hospital Universitario de Getafe, Getafe, Spain.
Anabela P RoloCenter for Neurosciences & Cell Biology of the University of Coimbra, Coimbra, Portugal; Department of Life Sciences of the Faculty of Sciences & Technology of the University of Coimbra, Coimbra, Portugal.
Francis RoussetDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Tatjana RuskovskaFaculty of Medical Sciences, Goce Delcev University, Stip, Republic of Macedonia.
Nuno SaraivaCBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
Shlomo SassonInstitute for Drug Research, Section of Pharmacology, Diabetes Research Unit, The Hebrew University Faculty of Medicine, Jerusalem, Israel.
Katrin SchröderInstitute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany.
Khrystyna SemenDanylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Tamara SeredeninaDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Anastasia ShakirzyanovaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Geoffrey L SmithDepartment of Pathology, University of Cambridge, Cambridge, UK.
Thierry SoldatiDepartment of Biochemistry, Science II, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva-4, Switzerland.
Bebiana C SousaSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Corinne M SpickettLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Ana StancicUniversity of Belgrade, Institute for Biological Research "Sinisa Stankovic" and Faculty of Biology, Belgrade, Serbia.
Marie José StasiaUniversité Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, F38000 Grenoble, France; CDiReC, Pôle Biologie, CHU de Grenoble, Grenoble, F-38043, France.
Holger SteinbrennerInstitute of Nutrition, Department of Nutrigenomics, Friedrich Schiller University, Jena, Germany.
Višnja StepanićRuđer Bošković Institute, Division of Molecular Medicine, Zagreb, Croatia.
Sebastian StevenMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Kostas TokatlidisInstitute of Molecular Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow, UK.
Erkan TuncayDepartment of Biophysics, Ankara University, Faculty of Medicine, 06100 Ankara, Turkey.
Belma TuranDepartment of Biophysics, Ankara University, Faculty of Medicine, 06100 Ankara, Turkey.
Fulvio UrsiniDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Jan VacekDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hnevotinska 3, Olomouc 77515, Czech Republic.
Olga VajnerovaDepartment of Physiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Kateřina ValentováInstitute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences, Videnska 1083, CZ-142 20 Prague, Czech Republic.
Frank Van BreusegemDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Lokman VarisliHarran University, Arts and Science Faculty, Department of Biology, Cancer Biology Lab, Osmanbey Campus, Sanliurfa, Turkey.
Elizabeth A VealInstitute for Cell and Molecular Biosciences, and Institute for Ageing, Newcastle University, Framlington Place, Newcastle upon Tyne, UK.
A Suha YalçınDepartment of Biochemistry, School of Medicine, Marmara University, İstanbul, Turkey.
Olha YelisyeyevaDanylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Neven ŽarkovićLaboratory for Oxidative Stress, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
Martina ZatloukalováDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hnevotinska 3, Olomouc 77515, Czech Republic.
Jacek ZielonkaMedical College of Wisconsin, Milwaukee, USA.
Rhian M TouyzInstitute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
Andreas PapapetropoulosLaboratoty of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
Tilman GruneGerman Institute of Human Nutrition, Department of Toxicology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Santiago LamasCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Madrid, Spain.
Harald H H W SchmidtDepartment of Pharmacology & Personalized Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Fabio Di LisaDepartment of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy. Electronic address: dilisa@bio.unipd.it.
Andreas DaiberMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany. Electronic address: daiber@uni-mainz.de.
University of Padua · ITAston University · GBUniversity of Glasgow · GBJohannes Gutenberg University Mainz · DEMaastricht University · NLAnkara University · TRUniversidad Autónoma de Madrid · ESDeutsches Herzzentrum München · DESemmelweis University · HUUniversity Medical Center of the Johannes Gutenberg University Mainz · DEUniversity of Cambridge · GBUniversity of Geneva · CHCentre de Recherche sur l'Inflammation · FRCharles University · CZCyprus Institute of Neurology and Genetics · CYCzech Academy of Sciences, Institute of Microbiology · CZDanylo Halytsky Lviv National Medical University · UAFlorida International University · USFreie Universität Berlin · DEHospital Universitario de Getafe · ES

Funding

British Heart Foundation RG/13/7/30099Medical Research Council G0900224NIDDK NIH HHS R01 DK103750
6 · The paper itself

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

Indexed as

International CooperationAnimalsEuropean UnionHumansMolecular BiologyOxidation-ReductionReactive Oxygen SpeciesSignal TransductionSocieties, ScientificReactive Oxygen SpeciesAntioxidantsOxidative stressReactive nitrogen speciesReactive oxygen speciesRedox signalingRedox therapeutics

Identifiers

PMID28577489
PMCPMC5458069
OpenAlexW2615563405

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