Evidence map›Paper›PMID 28580293›Full record

Trial reportNeuroImage. Clinical2017

Acupuncture modulates the abnormal brainstem activity in migraine without aura patients.

Zhengjie Li, Fang Zeng, Tao Yin, Lei Lan, Nikos Makris, Kristen Jorgenson, Taipin Guo, Feng Wu, Yujie Gao, Mingkai Dong and 6 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 12 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 12 syntheses or guidelines pooled it, 108 citations in OpenAlex.

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  12. Aberrant Spontaneous Low-Frequency Brain Activity in Migraine: A Meta-Analysis of Resting-State fMRI Studies.Journal of neuroimaging : official journal of the American Society of Neuroimaging
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Zhengjie LiThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Fang ZengThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Tao YinThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Lei LanThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Nikos MakrisDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, MA, USA; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Kristen JorgensonDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, MA, USA; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Taipin GuoThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Feng WuThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Yujie GaoThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Mingkai DongThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Mailan LiuAcupuncture & Tuina School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Jie YangThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Ying LiThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Qiyong GongHuaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Fanrong LiangThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address: acuresearch@126.com.
Jian KongDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, MA, USA; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Chengdu University of Traditional Chinese Medicine · CNAthinoula A. Martinos Center for Biomedical Imaging · USHunan University of Traditional Chinese Medicine · CNMassachusetts General Hospital · USWest China Hospital of Sichuan University · CN

Funding

NCCIH NIH HHS P01 AT006663NCCIH NIH HHS R01 AT006364NCCIH NIH HHS R01 AT008563NCCIH NIH HHS R21 AT008707
6 · The paper itself

Abstract

Migraine is a common neurological disease with a high prevalence and unsatisfactory treatment options. The specific pathophysiological mechanisms of migraine remain unclear, which restricts the development of effective treatments for this prevalent disorder. The aims of this study were to 1) compare the spontaneous brain activity differences between Migraine without Aura (MwoA) patients and healthy controls (HCs), using amplitude of low-frequency fluctuations (ALFF) calculation method, and 2) explore how an effective treatment (verum acupuncture) could modulate the ALFF of MwoA patients. One hundred MwoA patients and forty-six matched HCs were recruited. Patients were randomized to four weeks' verum acupuncture, sham acupuncture, and waiting list groups. Patients had resting state BOLD-fMRI scan before and after treatment, while HCs only had resting state BOLD-fMRI scan at baseline. Headache intensity, headache frequency, self-rating anxiety and self-rating depression were used for clinical efficacy evaluation. Compared with HCs, MwoA patients showed increased ALFF in posterior insula and putamen/caudate, and reduced ALFF in rostral ventromedial medulla (RVM)/trigeminocervical complex (TCC). After longitudinal verum acupuncture treatment, the decreased ALFF of the RVM/TCC was normalized in migraine patients. Verum acupuncture and sham acupuncture have different modulation effects on ALFF of RVM/TCC in migraine patients. Our results suggest that impairment of the homeostasis of the trigeminovascular nociceptive pathway is involved in the neural pathophysiology of migraines. Effective treatments, such as verum acupuncture, could help to restore this imbalance.

Indexed as

Outcome Assessment, Health CareAcupuncture TherapyAdultBrain StemFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMigraine without AuraNeural PathwaysNociceptionTrigeminal NerveYoung AdultAcupunctureAmplitude of low-frequency fluctuationsBrainstermMigraineResting state fMRITrigeminocervical complex

Identifiers

PMID28580293
PMCPMC5447510
OpenAlexW2617297161

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.