Trial reportDiabetes care2017
Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial.
Trial report in Diabetes care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Hybrid closed-loop insulin delivery improves glycaemic control compared with sensor-augmented pump therapy: A meta-analysis of 'free-living' randomised trials in type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2026Pooled it
- International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guidelines 2024: Diabetes Technologies - Insulin Delivery.Hormone research in paediatrics · 2024Guideline
- Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2018Pooled it
- Artificial Pancreas: Clinical Study in Latin America Without Premeal Insulin Boluses.Journal of diabetes science and technology · 2018Trial
- Real-Time Detection of Infusion Site Failures in a Closed-Loop Artificial Pancreas.Journal of diabetes science and technology · 2018Trial
- Fully Closed-Loop Multiple Model Probabilistic Predictive Controller Artificial Pancreas Performance in Adolescents and Adults in a Supervised Hotel Setting.Diabetes technology & therapeutics · 2018Trial
- Metabolic Models, in Silico Trials, and Algorithms.Diabetes technology & therapeutics · 2025Review
- Metabolic Models, in Silico Trials, and Algorithms.Journal of diabetes science and technology · 2025Review
- Glucose Rate-of-Change and Insulin-on-Board Jointly Weighted Zone Model Predictive Control.IEEE transactions on control systems technology : a publication of the IEEE Control Systems Society · 2023Article
- Effectiveness and safety of a model predictive control (MPC) algorithm for an artificial pancreas system in outpatients with type 1 diabetes (T1D): systematic review and meta-analysis.Diabetology & metabolic syndrome · 2022Review
- Feasibility of Closed-Loop Insulin Delivery with a Pregnancy-Specific Zone Model Predictive Control Algorithm.Diabetes technology & therapeutics · 2022Article
- Physical Activity and Psychological Stress Detection and Assessment of Their Effects on Glucose Concentration Predictions in Diabetes Management.IEEE transactions on bio-medical engineering · 2021Article
- Impact of Accelerating Insulin on an Artificial Pancreas System Without Meal Announcement: An In Silico Examination.Journal of diabetes science and technology · 2021Article
- Zone-MPC Automated Insulin Delivery Algorithm Tuned for Pregnancy Complicated by Type 1 Diabetes.Frontiers in endocrinology · 2021Article
- Embedded Model Predictive Control for a Wearable Artificial Pancreas.IEEE transactions on control systems technology : a publication of the IEEE Control Systems Society · 2020Article
- Monitoring of Pediatric Type 1 Diabetes.Frontiers in endocrinology · 2020Review
- Controlling the AP Controller: Controller Performance Assessment and Modification.Journal of diabetes science and technology · 2019Article
- Artificial Pancreas: Evaluating the ARG Algorithm Without Meal Announcement.Journal of diabetes science and technology · 2019Article
- Closed-Loop Control with Unannounced Exercise for Adults with Type 1 Diabetes using the Ensemble Model Predictive Control.Journal of process control · 2019Article
- Artificial Pancreas: Current Progress and Future Outlook in the Treatment of Type 1 Diabetes.Drugs · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveAs artificial pancreas (AP) becomes standard of care, consideration of extended use of insulin infusion sets (IIS) and continuous glucose monitors (CGMs) becomes vital. We conducted an outpatient randomized crossover study to test the safety and efficacy of a zone model predictive control (zone-MPC)-based AP system versus sensor augmented pump (SAP) therapy in which IIS and CGM failures were provoked via extended wear to 7 and 21 days, respectively. RESEARCH DESIGN AND
methodsA smartphone-based AP system was used by 19 adults (median age 23 years [IQR 10], mean 8.0 ± 1.7% HbA
resultsAP improved percent time 70-140 mg/dL (48.1 vs. 39.2%;
conclusionsZone-MPC significantly and safely improved glycemic control in a home-use environment despite prolonged CGM and IIS wear. This project represents the first home-use AP study attempting to provoke and detect component failure while successfully maintaining safety and effective glucose control.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.