Evidence map›Paper›PMID 28587495›Full record

ArticleFree radical research2017

Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin.

Dede N Ekoue, Soumen Bera, Emmanuel Ansong, Peter C Hart, Sofia Zaichick, Frederick E Domann, Marcelo G Bonini, Alan M Diamond

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dede N Ekouea Department of Pathology, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
Soumen Berab School of Life Sciences , B. S. Abdur Rahman University , India.
Emmanuel Ansonga Department of Pathology, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
Peter C Harta Department of Pathology, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
Sofia Zaichicka Department of Pathology, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
Frederick E Domannc Department of Radiation Oncology , University of Iowa , IA , USA.
Marcelo G Boninia Department of Pathology, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
Alan M Diamonda Department of Pathology, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
University of Illinois Chicago · USB.S. Abdur Rahman Crescent Institute of Science & Technology · INUniversity of Iowa · US

Funding

Colon Cancer Prevention with SeleniumR01CA127943 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIAMOND, ALAN · 2009 to 2013
$1.4M
The role of MnSOD allelic variations in prostate cancer etiology and outcomeR01CA193497 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIAMOND, ALAN, PRINS, GAIL S · 2015 to 2017
$1.2M
Anti-oxidant enzymes and prostate cancerR21CA182103 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIAMOND, ALAN · 2014 to 2015
$473k
NCI NIH HHS R01 CA127943NCI NIH HHS R01 CA193497NCI NIH HHS R21 CA182103
6 · The paper itself

Abstract

Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H

Indexed as

Gene Expression Regulation, NeoplasticAllelesAntigens, CDCadherinsCell EngineeringCell Line, TumorFemaleGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansHydrogen PeroxideMCF-7 CellsMitochondriaPhosphorylationPlasmidsPolymorphism, GeneticAntigens, CDBCL2 protein, humanCadherinsCDH1 protein, humanGlutathione PeroxidaseGlutathione Peroxidase GPX1GPX1 protein, humanHydrogen PeroxideProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2Sirt3 protein, mouseSirtuin 3Superoxide DismutaseBcl-2E-cadherinGPX1hydrogen peroxideMnSODSirt3

Identifiers

PMID28587495
PMCPMC5683088
OpenAlexW2622742041

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.