Evidence mapPaperPMID 28596241Full record

ArticleJournal of cell science2017

Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.

Qiang Feng, Edward M Bonder, Amy C Engevik, Lanjing Zhang, Matthew J Tyska, James R Goldenring, Nan Gao

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The predictive prognostic values ofAnnals of translational medicine · 2021
    Article
  10. Tight Junction Proteins Join the Local Force for Bulk Endocytosis and Microvillus Inclusion.Cellular and molecular gastroenterology and hepatology · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation inCellular and molecular gastroenterology and hepatology · 2018
    Article
  19. The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation.Cellular and molecular gastroenterology and hepatology · 2018
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qiang FengDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
Edward M BonderDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
Amy C EngevikDepartment of Surgery, and Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Lanjing ZhangDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
Matthew J TyskaDepartment of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
James R GoldenringDepartment of Surgery, and Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Nan GaoDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA ngao@andromeda.rutgers.edu.ORCID http://orcid.org/0000-0003-4264-7438
Rutgers, The State University of New Jersey · USVanderbilt University · US

Funding

Translational Analysis CoreP30DK058404 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2002 to 2025
$4.9M
SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSAR01DK048370 · VANDERBILT UNIVERSITY MEDICAL CENTER · 1994 to 2025
$3.1M
Surgical Oncology Training GrantT32CA106183 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2004 to 2025
$703k
Molecular basis of brush border assemblyR01DK095811 · VANDERBILT UNIVERSITY · 2025 to 2025
$526k
Role of actin bundlers during enterocyte differentiationR01DK111949 · VANDERBILT UNIVERSITY · 2025 to 2025
$451k
NCI NIH HHS R21 CA178599NCI NIH HHS T32 CA106183NIDDK NIH HHS F32 DK111101NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK048370NIDDK NIH HHS R01 DK075555NIDDK NIH HHS R01 DK095811NIDDK NIH HHS R01 DK102934NIDDK NIH HHS R01 DK111949
6 · The paper itself

Abstract

Misplaced formation of microvilli to basolateral domains and intracellular inclusions in enterocytes are pathognomonic features in congenital enteropathy associated with mutation of the apical plasma membrane receptor syntaxin 3 (STX3). Although the demonstrated binding of Myo5b to the Rab8a and Rab11a small GTPases

Indexed as

AnimalsEnterocytesGenetic Diseases, InbornIntestinal DiseasesMiceMice, KnockoutMicrovilliMyosin Type Vrab11 GTP-Binding Proteinsrab GTP-Binding ProteinsMyo5B protein, mouseMyosin Type Vrab11 GTP-Binding ProteinsRab8a protein, mouserab GTP-Binding ProteinsEnterocyteMicrovillus formationNeonatal enteropathyRab11aRab8a

Identifiers

PMID28596241
PMCPMC5558269
OpenAlexW2623022051

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.