Evidence map›Paper›PMID 28607108›Full record

ArticleDiabetes2017

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E Manning Fox and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. The involvement of KTranslational psychiatry · 2024
    Review
  12. Article
  13. Activity-dependent endoplasmic reticulum CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Microtubules in Pancreatic β Cells: Convoluted Roadways Toward Precision.Frontiers in cell and developmental biology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Jianyang FuAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Xiaoqing DaiAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Gregory PlummerAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Kunimasa SuzukiAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Austin BautistaAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
John M GithakaDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Laura SeniorAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Mette JensenSarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology & Cancer Biology and Medicine, Duke University, Durham, NC.
Dafna Greitzer-AntesDepartments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada.
Jocelyn E Manning FoxAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Herbert Y GaisanoDepartments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada.
Christopher B NewgardSarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology & Cancer Biology and Medicine, Duke University, Durham, NC.
Nicolas TouretDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Patrick E MacDonaldAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada pmacdonald@ualberta.ca.
University of Alberta · CADuke University · USUniversity of Toronto · CA

Funding

ENGINEERED GLUCOSE METABOLISM IN INSULIN-SECRETING CELLSR01DK046492 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI NEWGARD, CHRISTOPHER B · 1993 to 2025
$7.8M
Engineered Glucose Metabolism in Insulin Secreting CellsR37DK046492 · NIDDK · DUKE UNIVERSITY · PI NEWGARD, CHRISTOPHER B · 2003 to 2010
$3.5M
CIHR MOP310536CIHR MOP93659NIDDK NIH HHS R01 DK046492NIDDK NIH HHS R37 DK046492
6 · The paper itself

Abstract

Insulin exocytosis is regulated by ion channels that control excitability and Ca

Indexed as

ExocytosisAdultAgedAged, 80 and overBlood GlucoseCase-Control StudiesCell MembraneDiabetes Mellitus, Type 2FemaleGene Knockdown TechniquesHEK293 CellsHumansInsulinInsulin-Secreting CellsInsulin SecretionMaleBlood GlucoseInsulinKCNB1 protein, humanKCNB2 protein, humanShab Potassium ChannelsSTX1A protein, humanSyntaxin 1

Identifiers

PMID28607108
PMCPMC5482075
OpenAlexW2626777690

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.