ArticleHypertension (Dallas, Tex. : 1979)2017
Role of the Primary Cilia on the Macula Densa and Thick Ascending Limbs in Regulation of Sodium Excretion and Hemodynamics.
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Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Altered ciliary morphology reduces mechanosensation in a cystic kidney model as indicated by a mathematical model.Scientific reports · 2026Article
- Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition.Scientific reports · 2025Article
- Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters.Pflugers Archiv : European journal of physiology · 2022Review
- Profiling renal sodium transporters in mice with nephron Ift88 disruption: Association with sex, cysts, and blood pressure.Physiological reports · 2022Article
- Mechanistic Insight into Orthodontic Tooth Movement Based on Animal Studies: A Critical Review.Journal of clinical medicine · 2021Review
- A new view of macula densa cell microanatomy.American journal of physiology. Renal physiology · 2021Article
- Sensing of tubular flow and renal electrolyte transport.Nature reviews. Nephrology · 2020Review
- Tubule-vascular feedback in renal autoregulation.American journal of physiology. Renal physiology · 2019Review
- Nitric oxide mediates anomalous tubuloglomerular feedback in rats fed high-NaCl diet after subtotal nephrectomy.American journal of physiology. Renal physiology · 2019Article
- A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback.Current hypertension reports · 2019Review
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Authors and funding
10 authors.
Jiangping SongFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Lei WangFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Fan FanFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Jin WeiFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Jie ZhangFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Yan LuFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Yiling FuFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Shaohui WangFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Luis A JuncosFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.).
Ruisheng LiuFrom the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.). ruisheng@health.usf.edu.
Funding
Tubuloglomerular feedback and salt-sensitive hypertensionR01DK098582 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2013 to 2016
$1.3MPrimary cilia and modulation of the renal microcirculationR01DK099276 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2014 to 2017
$980kAnimal model of impaired autoregulation for study of age related vascular cognitive impairmentR21AG050049 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN · 2016 to 2017
$419kNIA NIH HHS R21 AG050049NIDDK NIH HHS R01 DK098582NIDDK NIH HHS R01 DK099276
Abstract
We investigated the significance of the primary cilia on the macula densa and thick ascending limb (TAL) in regulation of renal hemodynamics, sodium excretion, and blood pressure in this study. A tissue-specific primary cilia knock-out (KO) mouse line was generated by crossing NKCC2-Cre mice with IFT88-Δ/flox mice (NKCC2
Indexed as
AnimalsBlood PressureCiliaFeedback, PhysiologicalGlomerular Filtration RateHemodynamicsJuxtaglomerular ApparatusKidney GlomerulusKidney TubulesMiceModels, AnimalNitric OxideRenal EliminationSodium ChlorideNitric OxideSodium Chlorideblood pressureciliadietkidneymice
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What Socratic holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.