Evidence map›Paper›PMID 28611473›Full record

ArticleImmunology and cell biology2017

APC-targeted proinsulin expression inactivates insulin-specific memory CD8

Peta Ls Reeves, Rajeev Rudraraju, Xiao Liu, F Susan Wong, Emma E Hamilton-Williams, Raymond J Steptoe

Abstract read
PubMed Publisher
In one paragraph

Article in Immunology and cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Peta Ls ReevesThe University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.
Rajeev RudrarajuThe University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.
Xiao LiuThe University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.
F Susan WongInstitute of Molecular &Experimental Medicine, Cardiff University School of Medicine, Cardiff, Wales.
Emma E Hamilton-WilliamsThe University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-4892-3691
Raymond J SteptoeThe University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.
University of Queensland · AUCardiff University · GB

Funding

Medical Research Council G0901155NIAID NIH HHS HHSN272201300006C
6 · The paper itself

Abstract

Type 1 diabetes (T1D) results from T-cell-mediated autoimmune destruction of pancreatic β cells. Effector T-cell responses emerge early in disease development and expand as disease progresses. Following β-cell destruction, a long-lived T-cell memory is generated that represents a barrier to islet transplantation and other cellular insulin-replacement therapies. Development of effective immunotherapies that control or ablate β-cell destructive effector and memory T-cell responses has the potential to prevent disease progression and recurrence. Targeting antigen expression to antigen-presenting cells inactivates cognate CD8

Indexed as

Adoptive TransferAnimalsAntigen-Presenting CellsAutoantigensCD8-Positive T-LymphocytesCells, CulturedDiabetes Mellitus, Type 1HumansImmune ToleranceImmunologic MemoryInsulinInsulin-Secreting CellsMaleMiceMice, Inbred NODMice, TransgenicAutoantigensInsulinProinsulinReceptors, Antigen, T-Cell

Identifiers

PMID28611473
OpenAlexW2626018453

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.