SynthesisMedicine2017
A systematic review and meta-analysis into the effect of lateral wedge arch support insoles for reducing knee joint load in patients with medial knee osteoarthritis.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Personalized training and orthopedic inserts bring significant benefits in the posturographic assessment of patients with early gonarthrosis - a randomized controlled trial.Scientific reports · 2026Trial
- A comparison between laterally wedged insoles and ankle-foot orthoses for the treatment of medial osteoarthritis of the knee: A randomized cross-over trial.Clinical rehabilitation · 2021Trial
- 3D-printed shoe soles with structural properties towards reducing knee adduction moments during walking.Frontiers in bioengineering and biotechnology · 2026Article
- Toe-In and Toe-Out Walking Patterns and Lateral Wedge Insoles: A Musculoskeletal Simulation and Probabilistic Modelling Assessment of Medial Tibiofemoral Cartilage Mechanics.Life (Basel, Switzerland) · 2025Article
- Effect of Lateral Wedge Insole With and Without Thigh and Abdominal Muscle Strengthening Exercises on the Balance of Young People With Genuvarum: A Randomize Controlled Trial.Health science reports · 2025Article
- Association of medial longitudinal arch height and stiffness with lower extremity alignment, pain, and disease severity in knee osteoarthritis: A cross-sectional study.Archives of rheumatology · 2024Article
- Association of the Degree of Varus Thrust during Gait Assessed by an Inertial Measurement Unit with Patient-Reported Outcome Measures in Knee Osteoarthritis.Sensors (Basel, Switzerland) · 2023Article
- Knee adduction moment decomposition: Toward better clinical decision-making.Frontiers in bioengineering and biotechnology · 2022Article
- [Insoles, knee braces and ankle-foot orthoses in the treatment of medial gonarthrosis : A literature review].Der Orthopade · 2020Review
- Biomechanical and Functional Improvements Gained by Proximal Tibia Osteotomy Correction of Genu Varum in Patients with Knee Pain.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2020Article
- The optimal degree of lateral wedge insoles for reducing knee joint load: a systematic review and meta-analysis.Archives of physiotherapy · 2019Review
- Extracorporeal shockwave therapy for the treatment of knee osteoarthritis: A retrospective study.Medicine · 2018Observational
- Shoe-Insole Technology for Injury Prevention in Walking.Sensors (Basel, Switzerland) · 2018Review
- Is the Wedged Insole an Effective Treatment Option When Compared with a Flat (Placebo) Insole: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate the immediate effects of lateral wedge arch support insoles (LWAS) on reducing the knee joint load in patients with medial knee osteoarthritis (OA) compared with an appropriate control.
methodsDatabases including Medline, EMBASE, Web of Science, Wiley Online Library, Cochrane library, and Google Scholar were searched with no limits on study date or language, from the earliest available date to October 31, 2016. The included studies had to have the aim of reducing knee load and have an appropriate control. The main measured values were the first and second peak external knee adduction moments (EKAM) and the knee adduction angular impulse (KAAI). The random-effects model was used for analyzing the eligible studies.
resultsNine studies met the inclusion criteria with a total of 356 participants of whom 337 received LWAS treatment. The risk of methodological bias scores (quality index) ranged from 21 to 27 of 32. Treatment with LWAS resulted in statistically significant reductions in the first peak EKAM (P = .005), the second peak EKAM (P = .01), and the KAAI (P = .03). However, among trials in which the control treatment was control shoes, the LWAS showed no associations on the first peak EKAM (P = .10) or the KAAI (P = .06); among trials in which the control treatment was neutral insoles, the LWAS showed no associations on the second peak EKAM (P = .21) or the KAAI (P = .23). At the same time, the LWAS showed no statistically significant reduction on the first peak EKAM (P = .39) when compared with flat insoles.
conclusionAlthough meta-analysis outcomes of all studies indicated statistically significant associations between LWAS and reductions of the first peak EKAM, second peak EKAM and KAAI in people with medial knee OA while walking, different results existed in subgroups using various control conditions for comparison. These findings do not support the use of LWAS insoles for reducing knee load. An optimal LWAS treatment should provide the appropriate height of arch support and amount of lateral wedging. Further research should investigate the best combination of these 2 parameters to achieve efficacy without altered comfort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.