Evidence map›Paper›PMID 28615996›Full record

ReviewJournal of the International Society of Sports Nutrition2017

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.

Richard B Kreider, Douglas S Kalman, Jose Antonio, Tim N Ziegenfuss, Robert Wildman, Rick Collins, Darren G Candow, Susan M Kleiner, Anthony L Almada, Hector L Lopez

6 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the International Society of Sports Nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 382 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
382citing papers in PubMed, 27 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04058002 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Project Arthritis Recovering Quality of Life Through Education 70+

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2019 to 2020Enrolled34ConditionsKnee OsteoarthritisArmsMultiprofessional treatment and Educational Program Associated (EPA+C+BCAA) with supplementation of creatine and BCAA., Multiprofessional treatment and Educational Program Associated (EPA+C) with supplementation of creatine only.
NCT04290819 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effects of Creatine and Caffeine Co-Supplementation on Muscle Mass and Muscle Performance in Trained Young Adults

TypeinterventionalSponsorUniversity of ReginaRan2019 to 2020Enrolled36ConditionsPerformance Enhancing Product UseArmsCreatine Monohydrate, Creatine Monohydrate and Caffeine, Caffeine, Placebo
NCT04298840 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

Influence of Creatine Monohydrate Supplementation on Androgens and Global Hair Assessments

TypeinterventionalSponsorTexas Tech UniversityRan2020 to 2021Enrolled0ConditionsDihydrotestosterone, Testosterone, Hair LossArmsCreatine Monohydrate Supplementation, Placebo Supplementation
NCT05562232 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol

TypeinterventionalSponsorPsychiatric Research Unit, Region Zealand, DenmarkRan2023 to 2024Enrolled45ConditionsMild Traumatic Brain Injury, Concussion, BrainArmsCreatine Monohydrate
NCT05878106 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Creatine Supplementation and Resistance Training in Patients With Breast Cancer (CaRTiC Study)

TypeinterventionalSponsorUniversity of DeustoRan2024 to 2025Enrolled120ConditionsBreast Cancer, Supplementation, Resistance Training, Physical PerformanceArmsCreatine supplementation, Resistance training
NCT07593014 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Creatine Monohydrate Supplementation During Repeated Heat Exposure: Effects on Fluid Balance and Exercise Performance in a Randomized Double-Blind, Placebo-Controlled Trial

TypeinterventionalSponsorUniversity of WindsorRan2026 to 2027Enrolled25ConditionsHeat Exposure, Exercise Performance, Hydration, Body Fluid CompartmentsArmsCreatine Monohydrate, Maltodextrin (Placebo)
3 · Its place in the literature

Who cites it

382 citing papers in PubMed, 27 syntheses or guidelines pooled it, 772 citations in OpenAlex.

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322 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Richard B KreiderExercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843-4243 USA.
Douglas S KalmanNutrition Research Unit, QPS, 6141 Sunset Drive Suite 301, Miami, FL 33143 USA.
Jose AntonioDepartment of Health and Human Performance, Nova Southeastern University, Davie, FL 33328 USA.
Tim N ZiegenfussThe Center for Applied Health Sciences, 4302 Allen Road, STE 120, Stow, OH 44224 USA.
Robert WildmanPost Active Nutrition, 111 Leslie St, Dallas, TX 75208 USA.
Rick CollinsCollins Gann McCloskey & Barry, PLLC, 138 Mineola Blvd., Mineola, NY 11501 USA.
Darren G CandowFaculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2 Canada.
Susan M KleinerHigh Performance Nutrition, LLC, Mercer Island, WA 98040 USA.
Anthony L AlmadaVitargo Global Sciences, Inc., Dana Point, CA 92629 USA.
Hector L LopezThe Center for Applied Health Sciences, 4302 Allen Road, STE 120, Stow, OH 44224 USA.
Bedford Research Foundation · USMercer Island School District · USNew York College of Traditional Chinese Medicine · USNova Southeastern University · USNutrition 21 (United States) · USSunset Laboratory (United States) · USTexas A&M University · USUniversity of Regina · CAVital Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations. In addition to athletic and exercise improvement, research has shown that creatine supplementation may enhance post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and concussion and/or spinal cord neuroprotection. Additionally, a number of clinical applications of creatine supplementation have been studied involving neurodegenerative diseases (e.g., muscular dystrophy, Parkinson's, Huntington's disease), diabetes, osteoarthritis, fibromyalgia, aging, brain and heart ischemia, adolescent depression, and pregnancy. These studies provide a large body of evidence that creatine can not only improve exercise performance, but can play a role in preventing and/or reducing the severity of injury, enhancing rehabilitation from injuries, and helping athletes tolerate heavy training loads. Additionally, researchers have identified a number of potentially beneficial clinical uses of creatine supplementation. These studies show that short and long-term supplementation (up to 30 g/day for 5 years) is safe and well-tolerated in healthy individuals and in a number of patient populations ranging from infants to the elderly. Moreover, significant health benefits may be provided by ensuring habitual low dietary creatine ingestion (e.g., 3 g/day) throughout the lifespan. The purpose of this review is to provide an update to the current literature regarding the role and safety of creatine supplementation in exercise, sport, and medicine and to update the position stand of International Society of Sports Nutrition (ISSN).

Indexed as

Dietary SupplementsAthletic InjuriesAthletic PerformanceCreatineExerciseHumansPerformance-Enhancing SubstancesSocieties, ScientificSports Nutritional SciencesCreatinePerformance-Enhancing SubstancesAdolescentsAthletesChildrenClinical applicationsErgogenic aidsMuscle powerMuscular strengthPerformance enhancementSafetySport nutrition

Identifiers

PMID28615996
PMCPMC5469049
OpenAlexW2625882999

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.