Evidence map›Paper›PMID 28620773›Full record

SynthesisEuropean archives of psychiatry and clinical neuroscience2018

Antioxidant uric acid in treated and untreated subjects with major depressive disorder: a meta-analysis and meta-regression.

Francesco Bartoli, Giulia Trotta, Cristina Crocamo, Maria Rosaria Malerba, Massimo Clerici, Giuseppe Carrà

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesco BartoliDepartment of Medicine and Surgery, University of Milano Bicocca, Via Cadore 48, 20900, Monza, Italy. f.bartoli@campus.unimib.it.ORCID http://orcid.org/0000-0003-2612-4119
Giulia TrottaDepartment of Medicine and Surgery, University of Milano Bicocca, Via Cadore 48, 20900, Monza, Italy.
Cristina CrocamoDepartment of Medicine and Surgery, University of Milano Bicocca, Via Cadore 48, 20900, Monza, Italy.
Maria Rosaria MalerbaDepartment of Medicine and Surgery, University of Milano Bicocca, Via Cadore 48, 20900, Monza, Italy.
Massimo ClericiDepartment of Medicine and Surgery, University of Milano Bicocca, Via Cadore 48, 20900, Monza, Italy.
Giuseppe CarràDepartment of Medicine and Surgery, University of Milano Bicocca, Via Cadore 48, 20900, Monza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathophysiological mechanisms of major depressive disorder (MDD) seem to be associated with oxidative stress pathways and altered purinergic metabolism. We conducted a systematic review and meta-analysis to estimate if subjects with MDD might have reduced levels of antioxidant uric acid, considering also potential influence of antidepressant treatment. We searched the main Electronic Databases, identifying 14 studies that met our inclusion criteria. Meta-analyses were carried out generating pooled Hedges' g and mean differences (MDs), using random-effects models. Heterogeneity across studies and risk of publication bias were estimated using standard methods. Relevant sensitivity and meta-regression analyses were conducted. Subjects with MDD had levels of uric acid lower than healthy controls (Hedges' g = -0.30; p = 0.003). Overall between-study heterogeneity was high (I

Indexed as

AntioxidantsFemaleHumansMajor Depressive DisorderMaleUric AcidAntioxidantsUric AcidAntidepressive agentsMajor depressive disorderMeta-analysisUric acid

Identifiers

PMID28620773

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.