ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 28 citations in OpenAlex.
- Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies.Annals of neurology · 2019Trial
- Mitochondrial protein import stress causes lysosomal damage and progressive tissue atrophy.EMBO reports · 2026Article
- Family-Based GWAS of Cognitive Endophenotypes Reveals Genetic Architecture of Memory and Executive Function in Alzheimer's Disease.Current issues in molecular biology · 2026Article
- Genetic modifiers of APOE-ε4-associated cognitive decline.Nature communications · 2026Article
- Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Beyond the Genotype: A Multi-Omic Analysis of APOEe4's Role in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Genotyping TOMM40'523 poly-T polymorphisms using whole-genome sequencing.HGG advances · 2025Article
- Article
- The interplay between age at menopause and synaptic integrity on Alzheimer's disease risk in women.Science advances · 2025Article
- Alzheimer's disease-associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p-tau, synaptic peptides, and physical activity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease.Nature communications · 2024Article
- Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.Research square · 2024Article
- Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association withFrontiers in aging neuroscience · 2024Article
- Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Neurobiology of aging · 2023Article
- Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.JAMA neurology · 2023Article
- An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration.Scientific reports · 2022Article
- To what degree is late life cognitive decline driven by age-related neuropathologies?Brain : a journal of neurology · 2021Article
- TOMM40 '523' poly-T repeat length is a determinant of longitudinal cognitive decline in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Reassessment of Pioglitazone for Alzheimer's Disease.Frontiers in neuroscience · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionThe study investigated the role of neuropathologies in the relationship between TOMM40 '523 genotype and late-life cognitive decline.
methodsParticipants were community-dwelling older persons who had annual cognitive assessments and brain autopsies after death. Genotyping used DNA from peripheral blood or postmortem brain tissue. Linear mixed models assessed the extent to which the association of '523 genotype with cognitive decline is attributable to neuropathologies.
resultsRelative to ε3/ε3 homozygotes with '523-S/VL or '523-VL/VL genotype, both '523-L carriers and ε3/ε3 homozygotes with '523-S/S genotype had faster cognitive decline. The association of '523-L with cognitive decline was attenuated and no longer significant after controlling for Alzheimer's and other neuropathologies. By contrast, the association of '523-S/S was unchanged. DISCUSSION: There are two distinct TOMM40 '523 signals in relation to late-life cognitive decline. One signal primarily acts through AD and other common neuropathologies, whereas the other operates through a different mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.