ArticleEuropean radiology2017
Development of pancreatic cancer is predictable well in advance using contrast-enhanced CT: a case-cohort study.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- From Bench to Bedside: The Path Toward Real-World Translation for Artificial Intelligence in Pancreatic Cancer Detection.Korean journal of radiology · 2026Review
- Appearance of Pancreas Predictive of Cancer Presence: Utility of Computed Tomography Volumetry.Cancers · 2026Article
- Validation of a Pretrained Artificial Intelligence Model for Pancreatic Cancer Detection on Diagnosis and Prediagnosis Computed Tomography Scans.Investigative radiology · 2026Article
- Advancements in Radiomics-Based AI for Pancreatic Ductal Adenocarcinoma.Bioengineering (Basel, Switzerland) · 2025Review
- Diagnostic Value of Serum D-dimer, CA19-9, and CT Imaging Features in Pancreatic Ductal Adenocarcinoma and Benign Pancreatic Lesions.Journal of Cancer · 2025Article
- Temporal progression of pancreatic cancer computed tomography findings until diagnosis: A large-scale multicenter study.United European gastroenterology journal · 2024Article
- Proteomics-Driven Biomarkers in Pancreatic Cancer.Proteomes · 2023Review
- Artificial intelligence in pancreatic cancer: diagnosis, limitations, and the future prospects-a narrative review.Journal of cancer research and clinical oncology · 2023Review
- A retrospective preliminary study of intrapancreatic late enhancement as a noteworthy imaging finding in the early stages of pancreatic adenocarcinoma.European radiology · 2023Article
- Article
- Prevalence, features, and explanations of missed and misinterpreted pancreatic cancer on imaging: a matched case-control study.Abdominal radiology (New York) · 2022Article
- Application of artificial intelligence to pancreatic adenocarcinoma.Frontiers in oncology · 2022Review
- Recent advances in artificial intelligence for pancreatic ductal adenocarcinoma.World journal of gastroenterology · 2021Review
- Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings.Diagnostics (Basel, Switzerland) · 2021Article
- Computed tomography findings for predicting the future occurrence of pancreatic cancer: value of pancreatic volumetry.International journal of clinical oncology · 2021Article
- Review
- Computerized tomography scan in pre-diagnostic pancreatic ductal adenocarcinoma: Stages of progression and potential benefits of early intervention: A retrospective study.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020Article
- Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients.Diagnostics (Basel, Switzerland) · 2020Article
- Pancreatic Fat Infiltration Is Associated with a Higher Risk of Pancreatic Ductal Adenocarcinoma.Visceral medicine · 2020Article
- Early detection and imaging strategies to reveal and target developing pancreatic cancer.Expert review of anticancer therapy · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the radiological findings prognostic for the development of pancreatic adenocarcinoma in a cohort of patients with hepatocellular carcinoma, using multiphasic computed tomography (CT).
methodsA case-cohort study performed in a single university hospital. A database of patients who received hepatocellular carcinoma (HCC) treatment and trimonthly follow-up with four-phase dynamic CT was used (n = 1848). The cohort group was randomly extracted from the database (n = 103). The case group comprised nine patients from the database who developed pancreatic adenocarcinoma. The radiological findings were assessed during follow-up (average, 32 months).
resultsThe incidence of pancreatic mass, inhomogeneous parenchyma, loss of fatty marbling and main pancreatic duct dilatation gradually increased from 4 to 13 months before the diagnosis of pancreatic adenocarcinoma. There was a significantly higher incidence of pancreatic mass, inhomogeneous parenchyma and loss of fatty marbling on CT at baseline (average, 34 months before diagnosis) in the case group compared with the cohort group (P values < 0.01) and those findings at baseline were revealed as prognostic factors for pancreatic carcinogenesis, respectively (log-rank test, P values < 0.001).
conclusionsSeveral radiological findings observed on multiphasic CT can assist in predicting pancreatic carcinogenesis well in advance. KEY POINTS: • Pancreatic findings in multiphasic CT help predict development of pancreatic adenocarcinoma. • Key findings are mass, inhomogeneous parenchyma and loss of fatty marbling. • Those findings were observed 34 months before confirmed diagnosis of adenocarcinoma. • Those findings were prognostic factors for pancreatic carcinogenesis.
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