Evidence map›Paper›PMID 28631728›Full record

GuidelineThe American journal of gastroenterology2017

ACG and CAG Clinical Guideline: Management of Dyspepsia.

Paul Moayyedi, Brian E Lacy, Christopher N Andrews, Robert A Enns, Colin W Howden, Nimish Vakil

Erratum issuedAbstract readPractice GuidelineReview
PubMed Publisher
In one paragraph

Guideline in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 264 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 16 pooled it
53.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 16 syntheses or guidelines pooled it, 646 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. First regional consensus on the management ofWorld journal of gastroenterology · 2025
    Guideline
  5. Pooled it
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  8. Guidelines on optimizing the use of proton pump inhibitors: PPI stewardship.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023
    Guideline
  9. Guideline
  10. Pooled it
  11. Herbal medicine,Frontiers in pharmacology · 2023
    Pooled it
  12. Guideline
  13. Guideline
  14. Guideline
  15. Guideline
  16. Pooled it
  17. Trial
  18. Trial
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204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Paul MoayyediDivision of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.
Brian E LacyDivision of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Christopher N AndrewsDepartment of Medicine, University of Calgary, Calgary, Alberta, Canada.
Robert A EnnsDivision of Gastroenterology, St Paul's Hospital, University of British Columbia, Pacific Gastroenterology Associates, Vancouver, British Columbia, Canada.
Colin W HowdenDivision of Gastroenterology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Nimish VakilUniversity of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Allergan (Ireland) · IEDartmouth–Hitchcock Medical Center · USJanssen (Belgium) · BETakeda (United States) · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have updated both the American College of Gastroenterology (ACG) and the Canadian Association of Gastroenterology (CAG) guidelines on dyspepsia in a joint ACG/CAG dyspepsia guideline. We suggest that patients ≥60 years of age presenting with dyspepsia are investigated with upper gastrointestinal endoscopy to exclude organic pathology. This is a conditional recommendation and patients at higher risk of malignancy (such as spending their childhood in a high risk gastric cancer country or having a positive family history) could be offered an endoscopy at a younger age. Alarm features should not automatically precipitate endoscopy in younger patients but this should be considered on a case-by-case basis. We recommend patients <60 years of age have a non-invasive test Helicobacter pylori and treatment if positive. Those that are negative or do not respond to this approach should be given a trial of proton pump inhibitor (PPI) therapy. If these are ineffective tricyclic antidepressants (TCA) or prokinetic therapies can be tried. Patients that have an endoscopy where no pathology is found are defined as having functional dyspepsia (FD). H. pylori eradication should be offered in these patients if they are infected. We recommend PPI, TCA and prokinetic therapy (in that order) in those that fail therapy or are H. pylori negative. We do not recommend routine upper gastrointestinal (GI) motility testing but it may be useful in selected patients.

Indexed as

Disease ManagementEndoscopy, GastrointestinalAntidepressive Agents, TricyclicDrug Therapy, CombinationDyspepsiaGastrointestinal AgentsHelicobacter InfectionsHelicobacter pyloriHumansProton Pump InhibitorsAntidepressive Agents, TricyclicGastrointestinal AgentsProton Pump Inhibitors

Identifiers

PMID28631728
OpenAlexW2694232428

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.