Evidence map›Paper›PMID 28654021›Full record

ReviewNutrients2017

Vitamin C, Aging and Alzheimer's Disease.

Fiammetta Monacelli, Erica Acquarone, Chiara Giannotti, Roberta Borghi, Alessio Nencioni

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it, 238 citations in OpenAlex.

  1. Pooled it
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  15. Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fiammetta MonacelliSection of Geriatrics, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa 16132, Italy. fiammetta.monacelli@unige.it.
Erica AcquaroneSection of Geriatrics, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa 16132, Italy. erica88im@hotmail.com.
Chiara GiannottiSection of Geriatrics, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa 16132, Italy. chiara.giannotti86@gmail.com.
Roberta BorghiSection of Geriatrics, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa 16132, Italy. robertaborghi@yahoo.it.
Alessio NencioniSection of Geriatrics, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa 16132, Italy. Alessio.Nencioni@unige.it.
University of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate genome integrity and stability, indicating a key role of targeted nutrition in healthy aging. Growing in vivo evidence supports the role of ascorbic acid in ameliorating factors linked to Alzheimer's disease (AD) pathogenesis, although evidence in humans yielded equivocal results. The neuroprotective role of ascorbic acid not only relies on the general free radical trapping, but also on the suppression of pro-inflammatory genes, mitigating neuroinflammation, on the chelation of iron, copper, and zinc, and on the suppression of amyloid-beta peptide (Aβ) fibrillogenesis. Epidemiological evidence linking diet, one of the most important modifiable lifestyle factors, and risk of Alzheimer's disease is rapidly increasing. Thus, dietary interventions, as a way to epigenetically modulate the human genome, may play a role in the prevention of AD. The present review is aimed at providing an up to date overview of the main biological mechanisms that are associated with ascorbic acid supplementation/bioavailability in the process of aging and Alzheimer's disease. In addition, we will address new fields of research and future directions.

Indexed as

AgingAlzheimer DiseaseAnimalsAscorbic AcidBrainDisease Models, AnimalEpigenomicsHumansNutrigenomicsObservational Studies as TopicOxidative StressPlaque, AmyloidRandomized Controlled Trials as TopicVascular DiseasesAscorbic Acidaging processAlzheimer’s diseaseascorbic acid

Identifiers

PMID28654021
PMCPMC5537785
OpenAlexW2724874603

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.