Evidence mapPaperPMID 28664624Full record

Trial reportPediatric diabetes2018

Adherence to a lifestyle program for youth with type 2 diabetes and its association with treatment outcome in the TODAY clinical trial.

Robert I Berkowitz, Marsha D Marcus, Barbara J Anderson, Linda Delahanty, Nisha Grover, Andrea Kriska, Lori Laffel, Amy Syme, Elizabeth Venditti, Dorothy J Van Buren and 4 more

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Pediatric diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00081328. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00081328 phase3completed

Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial

Ran2004Enrolled699Registered outcomes11Posted comparisons0ConditionsDiabetes Mellitus, Type IIArmsLifestyle Program, Metformin, Rosiglitazone
Open the trial in the graph
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. The Results of the Families Improving Together (FIT) for Weight Loss Randomized Trial in Overweight African American Adolescents.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Adolescents with Type 2 Diabetes: Overcoming Barriers to Effective Weight Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Robert I BerkowitzDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia and Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Marsha D MarcusDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Barbara J AndersonBaylor College of Medicine, Texas Children's Hospital, Houston, Texas.
Linda DelahantyDepartment of Medicine, Massachusetts General Hospital Diabetes Center and Harvard Medical School, Boston, Massachusetts.
Nisha GroverGeorge Washington University Biostatistics Center, Rockville, Maryland.ORCID 0000-0001-8196-0772
Andrea KriskaDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Lori LaffelJoslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9675-3001
Amy SymePediatric Endocrinology, Yale University, New Haven, Connecticut.
Elizabeth VendittiDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Dorothy J Van BurenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Denise E WilfleyDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Patrice YasudaDepartment of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, California.
Kathryn HirstGeorge Washington University Biostatistics Center, Rockville, Maryland.
TODAY Study Group
University of Pittsburgh · USGeorge Washington University · USWashington University in St. Louis · USBaylor College of Medicine · USChildren's Hospital of Philadelphia · USHarvard University · USJoslin Diabetes Center · USUniversity of Southern California · USYale University · US

Funding

Statistics Center for Pediatric Type 2 Diabetes TherapyU01DK061230 · GEORGE WASHINGTON UNIVERSITY · 2001 to 2005
$69.5M
ZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · UNIVERSITY OF SOUTHERN CALIFORNIA · 1985 to 2005
$43.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · MASSACHUSETTS GENERAL HOSPITAL · 1985 to 2005
$26.1M
ZIPRASIDONE IN TOURETTES SYNDROME, OBSESSIVE COMPULSIVE &PERVASIVE DEV. DISORDERM01RR000125 · YALE UNIVERSITY · 1985 to 2005
$20.7M
XANAX PET SCAN/IV LACTATE PANIC STUDYM01RR000036 · WASHINGTON UNIVERSITY · 1985 to 2005
$20.4M
ZORVIRAX ORAL SUSPENSION FOR SEVERE CHILDHOOD HERPES VIRUS INFECTIONSM01RR000069 · UNIVERSITY OF COLORADO DENVER · 1985 to 2005
$15.4M
PILOT STUDY--SECRETORY TARGETING IN PANCREATIC B CELLSP30DK036836 · JOSLIN DIABETES CENTER · 1986 to 2025
$12.1M
Washington University Institute of Clinical and Translational SciencesUL1TR002345 · WASHINGTON UNIVERSITY · 2025 to 2025
$9.3M
Trt. of Primary Hyperaldosteronism w/ACE Inhibitors &Angiotension Rec. BlockersM01RR014467 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2001 to 2005
$7.3M
WATER PRECAUTIONS AND TYMPANOSTOMY TUBESM01RR000084 · CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS · 1985 to 2005
$5.2M
Management of Pediatric Type 2 Diabetes MellitusU01DK061239 · CHILDRENS HOSPITAL OF PHILADELPHIA · 2001 to 2005
$4.6M
Multi-Center Study of the Treatment of T2DM in YouthU01DK061212 · YALE UNIVERSITY · 2001 to 2005
$3.9M
NCATS NIH HHS UL1 TR002345NCRR NIH HHS M01 RR000036NCRR NIH HHS M01 RR000043NCRR NIH HHS M01 RR000069NCRR NIH HHS M01 RR000084NCRR NIH HHS M01 RR000125NCRR NIH HHS M01 RR001066NCRR NIH HHS M01 RR014467NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1 RR025780NIDDK NIH HHS P30 DK036836NIDDK NIH HHS U01 DK061212NIDDK NIH HHS U01 DK061230NIDDK NIH HHS U01 DK061239NIDDK NIH HHS U01 DK061242NIDDK NIH HHS U01 DK061254
6 · The paper itself

Abstract

objectiveTo assess the association of proxies of behavioral adherence to the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) lifestyle program with changes in glycemic control and obesity in a multi-ethnic sample of youth with type 2 diabetes.

methodsThe TODAY clinical trial included an intensive lifestyle intervention to promote weight reduction. Adherence was assessed with measures of attendance at intervention sessions and rates of self-monitoring of diet and physical activity by participants and their caregivers. The relation between participant characteristics and consistency of proxies of adherence were examined across 3 phases of intervention.

resultsA total of 234 TODAY youth were randomized to the lifestyle program. Overall rate of session attendance was approximately 60% of planned sessions. Participants with an adequate dose of session attendance (≥75% attended) did not differ from those who attended <75% of sessions in glycemic control, but did have significantly greater reductions in percent overweight compared with those who attended fewer than 75% of sessions. Rates of self-monitoring were low and additional analysis was not possible.

conclusionsRates of session attendance were moderate in a lifestyle program for youth with type 2 diabetes, but levels of self-monitoring, considered a key lifestyle change behavior, were low. Glycemic control was not significantly associated with session attendance but reductions in percent overweight were. Given the salience of program attendance and self-monitoring to lifestyle weight management established in other populations, future research is needed to understand, develop, and promote strategies and interventions targeting weight loss to achieve improved glycemic control in youth diagnosed with type 2 diabetes.

Indexed as

Healthy LifestyleAdolescentAdolescent BehaviorBody Mass IndexChildChild BehaviorCohort StudiesDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansHyperglycemiaHypoglycemiaIntention to Treat AnalysisMalePatient ComplianceGlycated Hemoglobinhemoglobin A1c protein, humanadherencelifestyle interventionpediatric obesitytype 2 diabetes

Identifiers

PMID28664624
PMCPMC5748014
OpenAlexW2726972832

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.