Evidence map›Paper›PMID 28665164›Full record

ArticleNanomedicine (London, England)2017

Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis.

Mingzhen Zhang, Xiaoyu Wang, Moon Kwon Han, James F Collins, Didier Merlin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 2 syntheses or guidelines pooled it, 283 citations in OpenAlex.

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  9. Therapeutic potential of garlic-derived exosome like nanovesicles: challenge and opportunity.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mingzhen ZhangInstitute for Biomedical Sciences, Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30302, USA.
Xiaoyu WangFood Science & Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Moon Kwon HanInstitute for Biomedical Sciences, Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30302, USA.
James F CollinsFood Science & Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Didier MerlinInstitute for Biomedical Sciences, Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30302, USA.
Georgia State University · USUniversity of Florida · US

Funding

Molecular Mechanisms of Intestinal Metal Ion Transport During Iron-DeficiencyR01DK074867 · NIDDK · UNIVERSITY OF FLORIDA · PI COLLINS, JAMES F., VIDYASAGAR, SADASIVAN · 2007 to 2022
$5.1M
ROLE OF CD98 IN INTESTINAL PERMEABILITYR01DK071594 · NIDDK · GEORGIA STATE UNIVERSITY · PI MERLIN, DIDIER · 2006 to 2017
$3.3M
Divalent Metal-ion Transporter 1 as a Therapeutic Target to Optimize Intestinal Iron TransportR01DK109717 · NIDDK · UNIVERSITY OF FLORIDA · PI COLLINS, JAMES F. · 2016 to 2020
$2.6M
NIDDK NIH HHS R01 DK071594NIDDK NIH HHS R01 DK074867NIDDK NIH HHS R01 DK109717
6 · The paper itself

Abstract

aimTo develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy. MATERIALS &

methodsNanoparticles composed of edible ginger-derived lipid, termed ginger-derived lipid vehicles (GDLVs) were generated from ginger lipids through hydration of a lipid film, a commonly used method for a liposome fabrication. The morphology, biocompatibility and transfection efficiency of GDLVs loaded with siRNA-CD98 (siRNA-CD98/GDLVs) were characterized by standard methods.

resultsOrally administered siRNA-CD98/GDLVs were effectively targeted specifically to colon tissues, resulting in reduced expression of CD98.

conclusionThese GDLVs have great promise as efficient siRNA-delivery vehicles while potentially obviating issues related to the traditional synthetic nanoparticles. As such, they help shift the current paradigm of siRNA delivery away from artificially synthesized nanoparticles toward the use of naturally derived nanovehicles from edible plants.

Indexed as

Administration, OralAnimalsApoptosisCell LineColitis, UlcerativeColonDrug CarriersFusion Regulatory Protein-1Genetic TherapyHumansLipidsLiposomesMiceNanoparticlesParticle SizeRNA, Small InterferingDrug CarriersFusion Regulatory Protein-1LipidsLiposomesRNA, Small Interferingginger-derived lipids vehiclesnatural delivery systemoral administrationsiRNA

Identifiers

PMID28665164
PMCPMC5827822
OpenAlexW2724456265

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.