Evidence map›Paper›PMID 28676520›Full record

ArticleCirculation2017

Transcription Factor RUNX1 Regulates Platelet

Guangfen Mao, Natthapol Songdej, Deepak Voora, Lawrence E Goldfinger, Fabiola E Del Carpio-Cano, Rachel A Myers, A Koneti Rao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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  10. Intracranial Aneurysms Induced byFrontiers in neurology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guangfen MaoFrom Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).
Natthapol SongdejFrom Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).
Deepak VooraFrom Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).
Lawrence E GoldfingerFrom Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).
Fabiola E Del Carpio-CanoFrom Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).
Rachel A MyersFrom Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).
A Koneti RaoFrom Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.). koneti@temple.edu.
Duke University · USTemple University · US

Funding

Development Of Prognostic Platelet RNA Biomarkers To Tailor Antiplatelet TherapyR01HL118049 · NHLBI · DUKE UNIVERSITY · PI VOORA, DEEPAK · 2013 to 2017
$3.9M
Human Platelet Defects in Transcription Factor RUNX1 HaplodeficiencyR01HL109568 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2013 to 2022
$3.4M
Novel small G protein pathway regulators of GPVI signaling in plateletsR01HL137207 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GOLDFINGER, LAWRENCE E, KUNAPULI, SATYA P. · 2017 to 2020
$2.5M
Aberrant Platelet Mechanisms in Inherited Human Platelet Function DisordersR01HL085422 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2007 to 2010
$1.5M
NHLBI NIH HHS R01 HL085422NHLBI NIH HHS R01 HL109568NHLBI NIH HHS R01 HL118049NHLBI NIH HHS R01 HL137207
6 · The paper itself

Abstract

backgroundPCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted in black subjects compared with white subjects. Little is known about the regulation of platelet

methodsWe pursued the hypothesis that

resultsPlatelet PCTP protein in the patient was reduced by ≈50%. DNA-protein binding studies showed RUNX1 binding to consensus sites in ≈1 kB of

conclusions

Indexed as

Blood PlateletsCell Line, TumorCohort StudiesComputational BiologyCore Binding Factor Alpha 2 SubunitHumansImmunoblottingMuramidasePeptide FragmentsPhospholipid Transfer ProteinsTranscription FactorsTransfectionCore Binding Factor Alpha 2 Subunithen egg lysozyme peptide (115-129)MuramidasePeptide FragmentsPhospholipid Transfer ProteinsRUNX1 protein, humanTranscription Factorsblood plateletscardiovascular diseasesphospholipid transfer proteinsRUNX1 protein, human

Identifiers

PMID28676520
PMCPMC5591032
OpenAlexW2724237471

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.