ArticleArthritis research & therapy2017
Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.
Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.Human cell · 2021Pooled it
- Dietary Diversity and Risk of Developing Gout: A Cohort Study of 161,213 Participants.Arthritis care & research · 2026Article
- A scoping review on cardiometabolic risk factors among Pacific Island populations and implications on future research in the region.American journal of epidemiology · 2026Article
- Comparison of two-stage methods for count data in Mendelian randomization: a simulation study.Journal of comparative effectiveness research · 2026Article
- Using Multi-Omics Methods to Understand Gouty Arthritis.Current rheumatology reviews · 2026Review
- A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES).Scientific reports · 2025Article
- Conducting genetic epidemiology research on hyperuricaemia and gout in an indigenous community in Guam - a feasibility study.BMC public health · 2025Article
- Exploring genetic structures and shared sites between alcohol, cheese intake, and inflammatory bowel disease.Frontiers in nutrition · 2025Article
- Genome-wide association studies and traditional Chinese medicine in hyperuricemia: current evidence and mechanistic insights.Frontiers in pharmacology · 2025Review
- A combination of red and processed meat intake and polygenic risk score influences the incidence of hyperuricemia in middle-aged Korean adults.Nutrition research and practice · 2024Article
- Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity.Arthritis research & therapy · 2024Article
- The association between theArhiv za higijenu rada i toksikologiju · 2023Article
- Susceptibility genes of hyperuricemia and gout.Hereditas · 2022Review
- Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study.BMC medicine · 2022Article
- Association between glucokinase regulator gene polymorphisms and serum uric acid levels in Taiwanese adolescents.Scientific reports · 2022Article
- Genetic risk of hyperuricemia in hypertensive patients associated with antihypertensive drug therapy: A longitudinal study.Clinical genetics · 2022Article
- Association and interaction between dietary patterns and gene polymorphisms in Liangshan residents with hyperuricemia.Scientific reports · 2022Article
- Trends in the Contribution of Genetic Susceptibility Loci to Hyperuricemia and Gout and Associated Novel Mechanisms.Frontiers in cell and developmental biology · 2022Review
- Why Does Hyperuricemia Not Necessarily Induce Gout?Biomolecules · 2021Review
- Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse.Biological psychiatry · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSome gout-associated loci interact with dietary exposures to influence outcome. The aim of this study was to systematically investigate interactions between alcohol exposure and urate-associated loci in gout.
methodsA total of 2792 New Zealand European and Polynesian (Māori or Pacific) people with or without gout were genotyped for 29 urate-associated genetic variants and tested for a departure from multiplicative interaction with alcohol exposure in the risk of gout. Publicly available data from 6892 European subjects were used to test for a departure from multiplicative interaction between specific loci and alcohol exposure for the risk of hyperuricemia (HU). Multivariate adjusted logistic and linear regression was done, including an interaction term.
resultsInteraction of any alcohol exposure with GCKR (rs780094) and A1CF (rs10821905) influenced the risk of gout in Europeans (interaction term 0.28, P = 1.5 × 10
conclusionsThese data support the hypothesis that alcohol influences the risk of gout via glucose and apolipoprotein metabolism. In the absence of alcohol exposure, genetic variants in the GCKR and A1CF genes have a stronger role in gout.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.