Evidence map›Paper›PMID 28679591›Full record

ArticleAmerican journal of physiology. Renal physiology2017

Greater transforming growth factor-β in adult female SHR is dependent on blood pressure, but does not account for sex differences in renal T-regulatory cells.

Ashlee J Tipton, Jacqueline B Musall, G Ryan Crislip, Jennifer C Sullivan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. LC-MS analysis ofRSC advances · 2020
    Article
  9. Review
  10. Article
  11. Recent advances in sex differences in kidney function.American journal of physiology. Renal physiology · 2019
    Article
  12. Article
  13. Article
  14. Sex and rigor: the TGF-β blood pressure affair.American journal of physiology. Renal physiology · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ashlee J TiptonDepartment of Physiology, Augusta University, Augusta, Georgia.
Jacqueline B MusallDepartment of Physiology, Augusta University, Augusta, Georgia.
G Ryan CrislipDepartment of Physiology, Augusta University, Augusta, Georgia.
Jennifer C SullivanDepartment of Physiology, Augusta University, Augusta, Georgia jensullivan@augusta.edu.
Augusta University · US

Funding

Mechanisms of T Cell-Mediated Hypertension In Females and MalesR01HL127091 · NHLBI · AUGUSTA UNIVERSITY · PI SULLIVAN, JENNIFER C · 2016 to 2019
$1.7M
NHLBI NIH HHS R01 HL127091
6 · The paper itself

Abstract

Female spontaneously hypertensive rats (SHR) have more renal regulatory T cells (Tregs) than males, and greater levels of Tregs in female SHR are dependent on blood pressure (BP). However, the molecular mechanism responsible for greater Tregs in female SHR is unknown. Transforming growth factor (TGF)-β is a pleiotropic cytokine critical in the differentiation of naïve T cells into Tregs, and female SHR have higher TGF-β excretion than male SHR. The goals of the current study were to test the hypotheses that

Indexed as

Sex CharacteristicsT-Lymphocytes, RegulatoryAnimalsAntihypertensive AgentsFemaleHypertensionKidneyMaleRats, Inbred SHRTransforming Growth Factor betaAntihypertensive AgentsTransforming Growth Factor betacytokineshypertensionlymphocytessex

Identifiers

PMID28679591
PMCPMC5668580
OpenAlexW2733456400

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.