Evidence map›Paper›PMID 28682240›Full record

ArticleeLife2017

Building bridges between cellular and molecular structural biology.

Ardan Patwardhan, Robert Brandt, Sarah J Butcher, Lucy Collinson, David Gault, Kay Grünewald, Corey Hecksel, Juha T Huiskonen, Andrii Iudin, Martin L Jones and 17 more

Abstract readConference Proceedings
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. EMDB-the Electron Microscopy Data Bank.Nucleic acids research · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Evolving data standards for cryo-EM structures.Structural dynamics (Melville, N.Y.) · 2020
    Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ardan PatwardhanCellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.ORCID 0000-0001-7663-9028
Robert BrandtVisualization Sciences Group, FEI, Mérignac, France.
Sarah J ButcherInstitute of Biotechnology and the Department of Biosciences, University of Helsinki, Helsinki, Finland.
Lucy CollinsonElectron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom.
David GaultCentre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom.
Kay GrünewaldDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Corey HeckselNational Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.
Juha T HuiskonenDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Andrii IudinCellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Martin L JonesElectron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom.ORCID 0000-0003-0994-5652
Paul K KorirCellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Abraham J KosterDepartment of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.
Ingvar LagerstedtEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Catherine L LawsonCenter for Integrative Proteomics Research and the Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, Piscataway, United States.
David MastronardeDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, United States.
Matthew McCormickKitware, Inc., Carrboro, United States.
Helen ParkinsonMolecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Peter B RosenthalStructural Biology of Cells and Viruses, Francis Crick Institute, London, United Kingdom.
Stephan SaalfeldJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-4106-1761
Helen R SaibilInstitute of Structural and Molecular Biology, Department of Crystallography, Birkbeck College, London, United Kingdom.
Sirarat SarntivijaiMolecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Irene Solanes ValeroEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Sriram SubramaniamLaboratory for Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Jason R SwedlowCentre for Gene Regulation and Expression and the Division of Computational Biology, University of Dundee, Dundee, United Kingdom.
Ilinca TudoseMolecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Martyn WinnScientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot, United Kingdom.
Gerard J KleywegtMolecular and Cellular Structure Cluster, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.

Funding

Unified Data Resource for Large Complexes Determined by Cryo-Electron MicroscopyR01GM079429 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2007 to 2021
$11.6M
Technology Development for 3D Electron MicroscopyZIABC010826 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SUBRAMANIAM, SRIRAM · 2009 to 2019
$9.1M
Biotechnology and Biological Sciences Research Council BB/G022577/1Medical Research Council MR/L007835Medical Research Council MR/L007835/1Medical Research Council MR/N009614/1Medical Research Council MR/P019544/1NIGMS NIH HHS R01 GM079429Wellcome Trust 104948
6 · The paper itself

Abstract

The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.

Indexed as

Cell BiologyComputational BiologyData CurationMacromolecular SubstancesMacromolecular Substancesbiophysicscomputational biologyelectron microscopyemdbempiarnoneontologysegmentationstructural biologysystems biologytomography

Identifiers

PMID28682240
PMCPMC5524535

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.