ArticleJournal of affective disorders2017
Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between brain activity and endogenous and exogenous cortisol - A systematic review.Psychoneuroendocrinology · 2020Pooled it
- Respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) modulates brain response to stress in major depression.Journal of psychiatric research · 2021Trial
- Neurobiological and emotional impact of occupational stress in frontline police officers: a neuroimaging and neurochemical study.European journal of psychotraumatology · 2025Article
- Age modulates the link between stress-related neural activity and mortality.Nature communications · 2025Article
- Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors.Biological psychiatry · 2024Article
- Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes.Biology of sex differences · 2024Article
- Neural response to stress differs by sex in young adulthood.Psychiatry research. Neuroimaging · 2023Article
- Blood biomarkers of post-stroke depression after minor stroke at three months in males and females.BMC psychiatry · 2022Article
- Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.Biological psychiatry · 2022Article
- Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Susceptibility of Women to Cardiovascular Disease and the Prevention Potential of Mind-Body Intervention by Changes in Neural Circuits and Cardiovascular Physiology.Biomolecules · 2021Review
- Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Impact of sex and depressed mood on the central regulation of cardiac autonomic function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Pre-scan cortisol is differentially associated with enhanced connectivity to the cognitive control network in young adults with a history of depression.Psychoneuroendocrinology · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundMaladaptive responses to negative affective stimuli are pervasive, including clinically ill and healthy people, and men and women respond differently at neural and hormonal levels. Inspired by the Research Domain Criteria initiative, we used a transdiagnostic approach to investigate the impact of sex and dysphoric mood on neural-hormonal responses to negative affective stimuli.
methodsParticipants included 99 individuals with major depressive disorder, psychosis and healthy controls. Functional magnetic resonance imaging (fMRI) was complemented with real-time acquisition of hypothalamo-pituitary-adrenal (HPA) and -gonadal (HPG) hormones. fMRI data were analyzed in SPM8 and task-related connectivity was assessed using generalized psychophysiological interaction.
resultsAcross all participants, elevated cortisol response predicted lower brain activity in orbitofrontal cortex and hypothalamus-amygdala connectivity. In those with worse dysphoric mood, elevated cortisol response predicted lower activity in hypothalamus and hippocampus. In women, elevated cortisol response was associated with lower activity in medial prefrontal cortex and low hypothalamo-hippocampal connectivity. In women with high dysphoric mood, elevated cortisol response was associated with low hypothalamo-hippocampal connectivity. There were no interactions with diagnosis or medication. LIMITATIONS: There was limited power to correct for multiple comparisons across total number of ROIs and connectivity targets; cortisol responses were relatively low.
conclusionsWe conclude that the pathophysiology in neural-hormonal responses to negative affective stimuli is shared across healthy and clinical populations and varies as a function of sex and dysphoric mood. Our findings may contribute to the development of hormonal adjunctive therapeutics that are sex-dependent, underscoring the importance of one's sex to precision medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.