Evidence map›Paper›PMID 28696430›Full record

ReviewMolecular psychiatry2017

Neuropathology of suicide: recent findings and future directions.

P-E Lutz, N Mechawar, G Turecki

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04159207 (A Longitudinal Study of Inflammatory Pathways in Depression), which is not on this map. Cited by 66 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04159207 completednot on this mapstarted 2019, after this paper: background citation

A Longitudinal Study of Inflammatory Pathways in Depression

TypeobservationalSponsorVan Andel Research InstituteRan2019 to 2023Enrolled130ConditionsMajor Depressive Disorder, Suicide, Attempted
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Suicide in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2019
    Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Article
  11. Suicide Behavior as a Distinct Psychobiology in Major Depression.Advances in experimental medicine and biology · 2026
    Review
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Reducing Depression and Suicidal Ideation Among Elder Abuse Victims Using PROTECT.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
    Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

P-E LutzMcGill Group for Suicide Studies, McGill University, Douglas Mental Health University Institute, Montreal, QC, Canada.
N MechawarMcGill Group for Suicide Studies, McGill University, Douglas Mental Health University Institute, Montreal, QC, Canada.
G TureckiMcGill Group for Suicide Studies, McGill University, Douglas Mental Health University Institute, Montreal, QC, Canada.

Funding

Epigenetic Marks of Cocaine AddictionR01DA033684 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MASH, DEBORAH C., TURECKI, GUSTAVO · 2011 to 2015
$3.6M
CIHR FDN148374CIHR MOP-111022CIHR MOP11260CIHR MOP119429CIHR MOP119430CIHR MOP93775NIDA NIH HHS R01 DA033684
6 · The paper itself

Abstract

Suicide is a major public health concern and a leading cause of death in most societies. Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It associates with multiple factors, including psychopathology, personality traits, early-life adversity and stressful life events, among others. Over the past decades, studies in fields ranging from neuroanatomy, genetics and molecular psychiatry have led to a model whereby behavioural dysregulation, including suicidal behaviour (SB), develops as a function of biological adaptations in key brain systems. More recently, the unravelling of the unique epigenetic processes that occur in the brain has opened promising avenues in suicide research. The present review explores the various facets of the current knowledge on suicidality and discusses how the rapidly evolving field of neurobehavioural epigenetics may fuel our ability to understand, and potentially prevent, SB.

Indexed as

BrainEpigenesis, GeneticEpigenomicsHumansLife Change EventsMental DisordersNervous System DiseasesNeuropathologyRisk FactorsSuicidal IdeationSuicideSuicide, Attempted

Identifiers

PMID28696430

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.