Evidence map›Paper›PMID 28696924›Full record

ArticleG3 (Bethesda, Md.)2017

The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in

Jill M Hoyt, Samuel K Wilson, Madhuri Kasa, Jeremy S Rise, Irini Topalidou, Michael Ailion

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jill M HoytDepartment of Biochemistry, University of Washington, Seattle, Washington 98195.
Samuel K WilsonDepartment of Biochemistry, University of Washington, Seattle, Washington 98195.
Madhuri KasaDepartment of Biochemistry, University of Washington, Seattle, Washington 98195.
Jeremy S RiseDepartment of Biochemistry, University of Washington, Seattle, Washington 98195.
Irini TopalidouDepartment of Biochemistry, University of Washington, Seattle, Washington 98195.
Michael AilionDepartment of Biochemistry, University of Washington, Seattle, Washington 98195 mailion@uw.edu.ORCID 0000-0002-8070-1362
University of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Regulation of Synaptic Transmission by GqR00MH082109 · NIMH · UNIVERSITY OF WASHINGTON · PI AILION, MICHAEL · 2011 to 2013
$726k
NIGMS NIH HHS T32 GM007270NIH HHS P40 OD010440NIMH NIH HHS R00 MH082109
6 · The paper itself

Abstract

Gq is a heterotrimeric G protein that is widely expressed in neurons and regulates neuronal activity. To identify pathways regulating neuronal Gq signaling, we performed a forward genetic screen in

Indexed as

Signal TransductionAcetylcholineAnimalsBehavior, AnimalCaenorhabditis elegansCaenorhabditis elegans ProteinsCholinergic NeuronsChromosome MappingEpistasis, GeneticGene Expression RegulationGenomeGTP-Binding Protein alpha Subunits, Gq-G11LocomotionMAP Kinase Kinase 4p38 Mitogen-Activated Protein KinasesWhole Genome SequencingAcetylcholineCaenorhabditis elegans ProteinsGTP-Binding Protein alpha Subunits, Gq-G11MAP Kinase Kinase 4p38 Mitogen-Activated Protein Kinasessek-1 protein, C elegansanimal behaviorC. elegansGq signalingp38 MAPK pathway

Identifiers

PMID28696924
PMCPMC5592925
OpenAlexW2735894113

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.