ArticleGenes & development2017
PRKCI promotes immune suppression in ovarian cancer.
Open access · diamondAbstract read
In one paragraph
Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Pooled it
- Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice.Neuroscience bulletin · 2026Article
- GARD: Genomic Data-Based Drug Repurposing in Head and Neck Cancer with Large Language Model Validation.Cancers · 2026Article
- GARD: Genomic Data based Drug Repurposing in Head and Neck Cancer with Large Language Model Validation.bioRxiv : the preprint server for biology · 2026Article
- MicroRNAs in Esophageal Cancer: Implications for Diagnosis, Progression, Prognosis and Chemoresistance.International journal of molecular sciences · 2026Review
- Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma.Cell reports · 2025Article
- Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions.MedComm · 2025Review
- Leveraging Real-World Data From a Clinicogenomic Database Addresses the Treatment Gap in Patients With High-Grade Serous Ovarian Cancer.JCO precision oncology · 2025Observational
- Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling.Cell communication and signaling : CCS · 2025Article
- Review
- Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis.Discover oncology · 2025Article
- A novel mitochondrial autophagy and aging-related gene signature for predicting ovarian cancer.Frontiers in immunology · 2025Article
- miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis.Biology direct · 2024Article
- Epigenome-Wide DNA Methylation in Unipolar Depression: Predictive Biomarker of Antidepressant Treatment Response?The international journal of neuropsychopharmacology · 2024Article
- PKCActa pharmaceutica Sinica. B · 2024Article
- Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios.Genome medicine · 2024Article
- Key players of immunosuppression in epithelial malignancies: Tumor-infiltrating myeloid cells and γδ T cells.Cancer reports (Hoboken, N.J.) · 2024Review
- Multidimensional analysis of tumor stem cells: from biological properties, metabolic adaptations to immune escape mechanisms.Frontiers in cell and developmental biology · 2024Review
- Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway.Frontiers in oncology · 2024Article
- Cell polarity changes in cancer initiation and progression.The Journal of cell biology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 7 institutions in 2 countries.
Sharmistha SarkarDepartment of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.ORCID 0000-0002-2274-2350
Christopher A BristowDepartment of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Prasenjit DeyDepartment of Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Kunal RaiDepartment of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Ruth PeretsDivision of Oncology, Clinical Research Institute at Rambam, Haifa 31096, Israel.
Alejandra Ramirez-CardenasDepartment of Environmental Health, Boston University, Boston, Massachusetts 02118, USA.
Shruti MalasiDepartment of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Emmet Huang-HobbsDepartment of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Monika HaemmerleDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Sherry Y WuDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Michael McGuireDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Alexei ProtopopovKEW Group, Cambridge, Massachusetts 02139, USA.
Shan JiangDepartment of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Joyce F LiuDepartment of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Michelle S HirschDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Qing ChangInstitute for Applied Cancer Science, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Alexander J LazarDepartment of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Anil K SoodDepartment of Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Ronny DrapkinDepartment of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Ronald DePinhoDepartment of Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Giulio DraettaDepartment of Genomic Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA.
Lynda ChinInstitute for Health Transformation, The University of Texas System, Houston, Texas 77030, USA.
The University of Texas MD Anderson Cancer Center · USHarvard University · USBoston University · USBrigham and Women's Hospital · USEnvironment and Health Group (United States) · USRambam Health Care Campus · ILThe University of Texas System · US
Funding
UNIVERSITY OF TEXAS MD ANDERSON SPORE IN OVARIAN CANCERP50CA083639 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C · 1999 to 2015
$33.0MNovel extra cellular RNA-based combinatorial RNA inhibition therapyUH3TR000943 · NCATS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., LOPEZ-BERESTEIN, GABRIEL · 2015 to 2017
$3.2MNCATS NIH HHS UH3 TR000943NCI NIH HHS P50 CA083639
Abstract
A key feature of high-grade serous ovarian carcinoma (HGSOC) is frequent amplification of the 3q26 locus harboring
Indexed as
Adaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell MovementCytokinesFemaleGene Expression Regulation, NeoplasticHumansImmune ToleranceIsoenzymesMiceMice, TransgenicOvarian NeoplasmsPhosphoproteinsProtein Kinase CProtein Kinase C-lambdaAdaptor Proteins, Signal TransducingCell Cycle ProteinsCytokinesIsoenzymesPhosphoproteinsProtein Kinase CProtein Kinase C-lambdaTumor Necrosis Factor-alphaYap1 protein, mouseYAP-Signaling Proteinsovarian cancerPRKCIYAP
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.