Evidence map›Paper›PMID 28700393›Full record

ArticleAIDS (London, England)2017

Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries.

Bora Youn, Theresa I Shireman, Yoojin Lee, Omar Galárraga, Aadia I Rana, Amy C Justice, Ira B Wilson

Open access · greenAbstract read
In one paragraph

Article in AIDS (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Use of antiretroviral therapy in nursing home residents with HIV.Journal of the American Geriatrics Society · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Trajectory of Physical Functioning Among Persons Living With HIV in Nursing Homes.Journal of the American Medical Directors Association · 2019
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Bora YounaDepartment of Health Services, Policy & Practice, Brown University School of Public Health bDepartment of Medicine, Alpert Medical School of Brown University, The Miriam Hospital, Providence, Rhode Island cDepartment of Internal Medicine, Yale School of Medicine, New Haven dVeterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.
Theresa I Shireman
Yoojin Lee
Omar Galárraga
Aadia I Rana
Amy C Justice
Ira B Wilson
Brown University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI CHEN, ELIZABETH S. · 2016 to 2025
$45.0M
Science/Technical CoreP2CHD041020 · NICHD · BROWN UNIVERSITY · PI ZHENCHAO QIAN · 2016 to 2026
$7.6M
Aging, comorbid conditions, and health care utilization in persons with HIVR01MH102202 · NIMH · BROWN UNIVERSITY · PI WILSON, IRA B · 2014 to 2017
$2.6M
Improving Retention in Care Among Postpartum HIV-infected Women in MississippiK23MH100955 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANA, AADIA · 2014 to 2018
$890k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS P30 AI042853NICHD NIH HHS P2C HD041020NIGMS NIH HHS U54 GM115677NIMH NIH HHS K23 MH100955NIMH NIH HHS R01 MH102202
6 · The paper itself

Abstract

objectiveWhether the rate of HIV antiretroviral therapy (ART) persistence has improved over time in the United States is unknown. We examined ART persistence trends between 2001 and 2010, using non-HIV medications as a comparator.

methodsWe conducted a retrospective cohort study using Medicaid claims. We defined persistence as the duration of treatment from the first to the last fill date before a 90-day permissible gap and used Kaplan-Meier curves and Cox proportional hazard models to assess crude and adjusted nonpersistence. The secular trends of ART persistence in 43 598 HIV patients were compared with the secular trends of persistence with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (ACEI/ARB), statins, and metformin in non-HIV-infected patients and subgroups of HIV patients who started these control medications while using ART.

resultsMedian time to ART nonpersistence increased from 23.9 months in 2001-2003 to 35.4 months in 2004-2006 and was not reached for those starting ART in 2007-2010. In adjusted models, ART initiators in 2007-2010 had 11% decreased hazard of nonpersistence compared with those who initiated in 2001-2003 (P < 0.001). For non-HIV patients initiating angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARB), statins, and metformin, the hazard ratios for nonpersistence comparing 2007-2010 to 2001-2003 were 1.07, 0.94, and 1.02, respectively (all P < 0.001). For HIV patients initiating the three control medications, the hazard ratios of nonpersistence comparing 2007-2010 to 2001-2003 were 0.71, 0.65, and 0.63, respectively (all P < 0.001).

conclusionPersistence with ART improved between 2001 and 2010. Persistence with control medications improved at a higher rate among HIV patients using ART than HIV-negative controls.

Indexed as

Medication AdherenceAdolescentAdultAgedAnti-Retroviral AgentsFemaleHIV InfectionsHumansMaleMedicaidMiddle AgedRetrospective StudiesUnited StatesYoung AdultAnti-Retroviral Agents

Identifiers

PMID28700393
PMCPMC5625296
OpenAlexW2616017090

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.