Evidence map›Paper›PMID 28701710›Full record

ArticleScientific reports2017

Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI.

Nicolás Santander, Carlos Lizama, María José Parga, Alonso Quiroz, Druso Pérez, Guadalupe Echeverría, Lorena Ulloa, Verónica Palma, Attilio Rigotti, Dolores Busso

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  7. Differential responses to maternal diabetes in embryo and visceral yolk sac.Frontiers in cell and developmental biology · 2023
    Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Antioxidants Promote Intestinal Tumor Progression in Mice.Antioxidants (Basel, Switzerland) · 2021
    Article
  14. Article
  15. Article
  16. Roles of vitamins in stem cells.Cellular and molecular life sciences : CMLS · 2020
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nicolás SantanderDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0001-8919-833X
Carlos LizamaCardiovascular Research Institute, University of California, San Francisco, California, USA.
María José PargaDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Alonso QuirozDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Druso PérezCenter of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Guadalupe EcheverríaCenter of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Lorena UlloaLaboratory of Stem Cell and Developmental Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile.
Verónica PalmaLaboratory of Stem Cell and Developmental Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile.
Attilio RigottiDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Dolores BussoDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. dbusso@med.puc.cl.
Pontificia Universidad Católica de Chile · CLUniversity of Chile · CLUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and vitamin E, between these particles and cells. During early development, SR-BI is expressed in extraembryonic tissue, specifically in trophoblast giant cells in the parietal yolk sac. We previously showed that approximately 50% of SR-BI

Indexed as

Embryonic Developmentalpha-TocopherolAnimalsBiomarkersCD36 AntigensDietary SupplementsGene Expression Regulation, DevelopmentalMiceMice, KnockoutNeural TubeOxidation-ReductionVitamin EYolk Sacalpha-TocopherolBiomarkersCD36 AntigensVitamin E

Identifiers

PMID28701710
PMCPMC5507922
OpenAlexW2732652816

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.