ReviewFrontiers in neuroendocrinology2017
Polymorphisms in sex steroid receptors: From gene sequence to behavior.
Review in Frontiers in neuroendocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Sex-dimorphic reprogramming of fetal mouse brain development by maternal estradiol excess.Biology of sex differences · 2025Article
- The complex interaction between oestrogen receptor genes, oestradiol, and perinatal mood.Dialogues in clinical neuroscience · 2025Article
- Longitudinal Analysis of Estrogen Receptor Gene Methylation, Estradiol, and Depressive Symptoms During the Perinatal Period.Molecular neurobiology · 2025Article
- ROLE OF POLYMORPHISMS IN VEGF AND KDR GENES IN OSTEOSARCOMA SUSCEPTIBILITY: A SYSTEMATIC REVIEW.Acta ortopedica brasileira · 2025Review
- Association between androgen receptor gene and behavioral traits in cats (Felis catus).PloS one · 2025Article
- PvuII-ESR1 gene polymorphism in premenstrual dysphoric disorder in South Indian women.Indian journal of psychiatry · 2024Article
- Non-Synonymous Substitutions in Cadherin 13, Solute Carrier Family 6 Member 4, and Monoamine Oxidase A Genes are Associated with Personality Traits in Thoroughbred Horses.Behavior genetics · 2024Article
- Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background.Hormones and behavior · 2023Article
- DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study.Clinical epigenetics · 2021Article
- Association between menopausal hormone therapy and risk of neurodegenerative diseases: Implications for precision hormone therapy.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity.Frontiers in psychiatry · 2021Article
- Inside the supergene of the bird with four sexes.Hormones and behavior · 2020Review
- Analysis of Four Polymorphisms Located at the Promoter of the Estrogen Receptor Alpha ESR1 Gene in a Population With Gender Incongruence.Sexual medicine · 2020Article
- Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour.Proceedings. Biological sciences · 2020Article
- Neuroendocrine stress response is moderated by sex and sex hormone receptor polymorphisms.Hormones and behavior · 2018Article
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- Rapid effects of estradiol on aggression depend on genotype in a species with an estrogen receptor polymorphism.Hormones and behavior · 2018Article
- Testosterone, Cortisol and Financial Risk-Taking.Frontiers in behavioral neuroscience · 2018Review
- Defining the Construct of Synthetic Androgen Intoxication: An Application of General Brain Arousal.Frontiers in psychology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Sex steroid receptors have received much interest as potential mediators of human behaviors and mental disorders. Candidate gene association studies have identified about 50 genetic variants of androgen and estrogen receptors that correlate with human behavioral phenotypes. Because most of these polymorphisms lie outside coding regions, discerning their effect on receptor function is not straightforward. Thus, although discoveries of associations improve our ability to predict risk, they have not greatly advanced our understanding of underlying mechanisms. This article is intended to serve as a starting point for psychologists and other behavioral biologists to consider potential mechanisms. Here, I review associations between polymorphisms in sex steroid receptors and human behavioral phenotypes. I then consider ways in which genetic variation can affect processes such as mRNA transcription, splicing, and stability. Finally, I suggest ways that hypotheses about mechanism can be tested, for example using in vitro assays and/or animal models.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.