Evidence map›Paper›PMID 28706949›Full record

ArticleBioMed research international2017

Genetic Variant of

Hong Li, Shasha Yu, Rui Wang, Zhaoqing Sun, Xinghu Zhou, Liqiang Zheng, Zhihua Yin, Xingang Zhang, Yingxian Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Study on potential differentially expressed genes in stroke by bioinformatics analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong LiDepartment of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Shasha YuDepartment of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.
Rui WangDepartment of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.
Zhaoqing SunDepartment of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Xinghu ZhouDepartment of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.
Liqiang ZhengDepartment of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Zhihua YinEpidemiology Department of China Medical University, No. 77 Puhe Road, Shenyang 110000, China.
Xingang ZhangDepartment of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.
Yingxian SunDepartment of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.ORCID 0000-0002-1961-899X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIschemic stroke is a complex disorder resulting from the interplay of genetic and environmental factors. Previous studies showed that kalirin gene variations were associated with cardiovascular disease. However, the association between this gene and ischemic stroke was unknown. We performed this study to confirm if kalirin gene variation was associated with ischemic stroke.

methodsWe enrolled 385 ischemic stroke patients and 362 controls from China. Three SNPs of kalirin gene were genotyped by means of ligase detection reaction-PCR method. Data was processed with SPSS and SHEsis platform.

resultsSNP rs7620580 (dominant model: OR = 1.590,

conclusionsOur results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population.

Indexed as

Genetic Predisposition to DiseaseAgedAllelesAsian PeopleChinaFemaleGenetic Association StudiesGenotypeGuanine Nucleotide Exchange FactorsHaplotypesHumansIschemiaMaleMiddle AgedPolymorphism, Single NucleotideProtein Serine-Threonine KinasesGuanine Nucleotide Exchange FactorsKALRN protein, humanProtein Serine-Threonine Kinases

Identifiers

PMID28706949
PMCPMC5494542

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.